Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Reexamination Certificate
2001-11-29
2008-09-09
Maier, Leigh C (Department: 1623)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
C424S009510, C424S009520, C424S450000
Reexamination Certificate
active
07422733
ABSTRACT:
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLeXcompositions. In particular, the disclosed SLeXcompounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLeXcompounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Lex, and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.
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Marinelli Edmund E.
Pillai Radhakrishua
Ramalingam Kondareddiar
Ranganathan Ramachandran
Swenson Rolf E.
Bracco International B.V.
Kramer Levin Naftalis & Frankel LLP
Maier Leigh C
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