Linezolid crystalline hydrate form and linezolid salts

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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Reexamination Certificate

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07989618

ABSTRACT:
Linezolid salts, useful as such and as intermediates in a process for the preparation of novel and known crystalline linezolid forms, in particular known as Form III.

REFERENCES:
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Brickner, Steven J., et al. “Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolindinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections,” J. Med. Chem, 1996, 39, pp. 673-679.
S.E. Schaus et al., “Dynamic Kinetic Resolution of Epichlorohydrin via Enantioselective Catalytic Ring Opening with TMSN3. Practical Synthesis of Aryl Oxazolidinone Antibacterial Agents,” Tetrahedron Letters, vol. 37, No. 44, pp. 7937-7940, 1996.

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