Linear process for the preparation of a morpholine compound

Details Linear process for the preparation of a morpholine compound Linear process for the preparation of a morpholine compound

1999-10-28

2000-04-18

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D41306

Patent

active

060517077

ABSTRACT:
The present invention is concerned with a novel linear process for the preparation of 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl) phenyl)-ethoxy)-4-(5-(dimethylamino)methyl-1,2,3-triazol-4-yl)methyl-3-(S) -(4-fluorophenyl)-morpholine which is a potent and selective substance P (or neurokinin-1) receptor antagonist usefull as a therapeutic agent.

REFERENCES:
patent: 5612337 (1997-03-01), Baker et al.

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