Linear high-throughput proteomics

Details Linear high-throughput proteomics Linear high-throughput proteomics

2006-07-12

2009-06-23

Weber, Jon P (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

07550259

ABSTRACT:
A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced into a mass spectrometer in the same sequential order so that, within a given time window, the digested proteins introduced into the mass spectrometer are covariant.

REFERENCES:
Walcher et al. “Characterization of a variant of the spinach PSII type I light-heavesting protein using kinetically controlled digestion and RP-HPLC-ESI-MS”, Anal. Chem. 2003, 75:6775-6780.
Mortz et al. “Mass spectrometric characterization of glycosylated interferon-gamma variants separated by gel electrophoresis”, 1996, 17:925-931.
Steen et al., “The ABC's (and XYZ's) of Peptide Sequencing”, Nature Reviews vol. 5, pp. 699-711 (2004).

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