Linear and monocyclic endothelin antagonists

Details Linear and monocyclic endothelin antagonists Linear and monocyclic endothelin antagonists

1991-06-14

1993-11-09

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 15, 514 16, 514 17, 514 18, 530326, 530327, 530328, 530329, 530330, 530331, 530317, A61K 3702, C07K 706, C07K 708

Patent

active

052602761

ABSTRACT:
Novel linear and monocyclic antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling hypertension, myocardial infarction, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute renal failure, preeclampsia, and diabetes.

REFERENCES:
patent: 4981950 (1991-01-01), Masaki et al.
patent: 5114918 (1992-05-01), Ishikawa et al.
Cody, W. et al., Chem. Abs., CA 116(11):99469h, 1992.
Komagaye, S. et al., Int. J. Peptide Prot. Res., 32:519-526, 1988.
Stewart, J. et al., Solid Phase Peptide Synthesis Pierce Chemical. Co., 1984.
Cody, W. L., et al. Abstract, Second International Conference on Endothelin, Tsukuba, Japan, Dec. 9, 1990.
Johansen, N. L., et al. Peptides 1990, Proceedings of the Twenty-First European Peptide Symposium, edited by Giralt, E. & Andreu, D., pp. 680-681, ESCOM Science Publishers B.V. (1990).

Affiliated with

Also associated with

Rating

Linear and monocyclic endothelin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Linear and monocyclic endothelin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Linear and monocyclic endothelin antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1142781