Linear aminoalkylphosphoramidate oligonucleotide derivatives

Details Linear aminoalkylphosphoramidate oligonucleotide derivatives Linear aminoalkylphosphoramidate oligonucleotide derivatives

1994-03-03

1996-10-08

Jones, W. Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 536 231, 536 2532, 536 2533, 536 2534, C07H 2100, C07H 2102, C07H 2104, C12Q 168

Patent

active

055632530

ABSTRACT:
Disclosed are methods of producing a synthetic oligonucleotide of selected nucleotide sequence which is internally functionalized at at least one selected location with an aminoalkyl-phosphoramidate and labelled with a nonradioactive material. Also disclosed are oligonucleotides produced by this method.

REFERENCES:
patent: 4762779 (1988-08-01), Snitman
patent: 4959463 (1990-09-01), Froehler et al.
patent: 4965349 (1990-10-01), Woo et al.
patent: 5321131 (1994-06-01), Agrawal et al.
Stein et al. Cancer Research 48:2659-2668, 1988.
Sokolora, N. I. et al. Doklady Akademii Nauk SSSR, 253(6): 1395-1398, 1980. (Enlish translated version is provided.).
Haralambidis et al. (1990) Nucleic Acids Res. 18:493-499.
Haralambidis et al. (1990) Nucleic Acids Res. 18:501-505.
Agrawal (1989) Tetrahedron Letters 30(50):7025-7028.
Fidanza & McLaughlin (1989) J. Am. Chem. Soc. 111:9117-9119.
Nelson et al. (1989) Nucleic Acids Res. 17:7187-7194.
Agrawal et al. (1988) Proc. Natl. Acad. Sci. USA 85:7079-7083.
Agrawal et al. (1988) J. Cell. Biology 107:468.
Cardullo et al. (1988) Proc. Natl. Acad. Sci. USA 85:8790-8794.
Froehler & Matteucci (1988) Nucleic Acids Res. 16:4831-4839.
Jager et al. (1988) Biochemistry 27:7237-7246.
Letsinger et al. (1988) J. Am. Chem. Soc. 110:4470-4471.
Matthews & Kricka (1988) Analytical Biochem. 169:1-25.
Agrawal and Goodchild (1987) Tetrahedron Letters 28(31):3539-3542.
Caruthers et al. (1987) Methods in Enzymology 154:287-313.
Le Doan et al. (1987) Nucleic Acids Res. 15:8643-8659.
Agrawal et al. (1986) Nucleic Acids Res. 14:6227-6245.
Nevinski et al. (1983) Chemical Abstracts 99(5):35050.
Dobranravova et al. (1983) Chemical Abstracts 97(7):53484.
Zwierzak A. (Aug. 1975) Synthesis International Journal of Methods in Synthetic Organic Chemistry "Communications" pp. 507-509.

Affiliated with

Also associated with

Rating

Linear aminoalkylphosphoramidate oligonucleotide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Linear aminoalkylphosphoramidate oligonucleotide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Linear aminoalkylphosphoramidate oligonucleotide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-58328