Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2005-05-31
2005-05-31
Hayes, Robert C. (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S375000, C435S368000
Reexamination Certificate
active
06900054
ABSTRACT:
A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+E-NCAM−glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+process-bearing astrocytes, and A2B5−fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
REFERENCES:
patent: 5688692 (1997-11-01), Jat et al.
patent: 5753506 (1998-05-01), Johe et al.
Gord et al. Developmental Biol. 167: 596-608, 1995.*
J. Price, et al.; The Generation of Cellular Diversity in the Cerebral Cortex, 2 Brain Pathology 23-29 (1992).
R. McKinnon, et al.; FGF Modulates the PDGF-Driven Pathway of Oligodenrocyte Development; 5 Neuron 603-614 (1990).
M. Raff, et al.; Two Types of Astrocytes in Cultures of Developing Rat White Matter: Differences in Morphology, Surface Gangliosides, and Growth Characteristics; 3 The Journal of Neuroscience 1289-1300 (1983).
R.K. Small, et al.; Evidence for migration of oligodendrocyte-type-2 astrocyte progenitor cells into the developing rat optic nerve; 328 Nature 155-157 (1987).
O. Bögler, et al.; Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells; 87 Proc. Natl. Acad. Sci, USA 6368-6372 (1990).
J. Sanes; Analysing cell lineage with a recombinant retrovirus; 12 TINS 21-28 (1989).
A.K. Groves, et al.; Repair of demyelinated lesions by transplantation of purified O-2Aprogenitor cells; 362 Nature 453-455 (1993).
J. E. Goldman; Lineage, migration, and fate determination of postnatal subventricular zone cells in the mammalian CNS; 24 Journal of Neuro-Oncology 61-64 (1995).
O. Bögler, et al.; Measurement of Time in Oligodendrocyte- Type-2 Astrocyte (O-2A) Progenitors Is a Cellular process Distinct from Differentiation or Division; 162 Developmental Biology 525-538 (1994).
J.B. Grinspan, et al.; Cerebral White Matter Contains PDGF-Responsive Precursors to O2A Cells; 10(6) The Journal of Neuroscience 1866-1873 (1990).
R. Hardy and R. Reynolds; Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo; 111 Development 1061-1080 (1991).
M. C. Raff, et al.; A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium; 303 Nature 390-396 (1983).
R. H. Miller, et al.; Clonal analysis of astrocyte diversity in neonatal rat spinal cord cultures; 113 Development 353-362 (1991).
M. Noble et al.; Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell; 3 The EMBO Journal 2243-2247 (1984).
M. Mayer, et al.; Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro; 120 Development 143-153 (1994).
M. Mayer-Proschel, et al.; Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells; 19 Neuron 773-785 (1997).
N. Ibarrola, et al.; Evidence for the Existence of at Least Two Timing Mechanisms That Contribute to Oligodendrocyte Generation in vitro; 180 Developmental Biology 1-21 (1996).
M. Noble, et al.; From Rodent Glial Precursor Cell to Human Glial Neoplasia in the Oligodendrocyte- Type-2 Astrocyte Lineage; 15 GLIA 222-230 (1995).
P.F. Bartlett, et al.; Rat Neural Anigen-2 (Ran-2): A Cell Surface Antigen on Astrocytes, Ependymal Cells, Müller Cells and Lepto-Me-Ninges Defined by a Monoclonal Antibody; 204Brain Research339-351 (1981).
M.C. Raff; Glial Cell Diversification in the Rat Optic Nerve; 243 Science 1450-1455 (1989).
R.H. Miller, et al.; The Macroglial Cells of The Rat Optic Nerve; 12 Ann. Rev. Neurosci. 517-534 (1989).
Z. Ikram, et al.; The biological clock that measures the mitotic life-span of mouse embryo fibroblats continues to function in the presence of simian virus 40 large tumor antigen; 91Proc. Natl. Acad. Sci. USA6448-6452 (1994).
Mayer-Proschel Margot
Noble Mark
Rao Mahendra S.
Hayes Robert C.
Licata & Tyrrell P.C.
University of Utah Research Foundation
LandOfFree
Lineage restricted glial precursors from the central nervous... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lineage restricted glial precursors from the central nervous..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lineage restricted glial precursors from the central nervous... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3456692