Lineage-directed induction of human mesenchymal stem cell differ

Details Lineage-directed induction of human mesenchymal stem cell differ Lineage-directed induction of human mesenchymal stem cell differ

1997-07-23

1999-08-24

Lankford, Jr., Leon B.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

435366, 435372, C12N 500

Patent

active

059422254

ABSTRACT:
Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including isolated culture expanded human mesenchymal stem cells and bioactive factors effective to induce directed lineage induction are disclosed. Further disclosed is this method which also includes introducing such culturally expanded lineage-induced mesenchymal stem cells into a host from which they have originated for purposes of mesenchymal tissue regeneration or repair.

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patent: 5591625 (1997-01-01), Gerson et al.
patent: 5612211 (1997-03-01), Wilson et al.
patent: 5733542 (1998-03-01), Haynesworth et al.
patent: 5736396 (1998-04-01), Bruder et al.

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