Lineage-directed induction of human mesenchymal stem cell differ

Details Lineage-directed induction of human mesenchymal stem cell differ Lineage-directed induction of human mesenchymal stem cell differ

1995-01-24

1998-04-07

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

453372, 424937, C12N 500, C12N 502

Patent

active

057363960

ABSTRACT:
Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including isolated culture expanded human mesenchymal stem cells and bioactive factors effective to induce directed lineage induction are disclosed. Further disclosed is this method which also includes introducing such culturally expanded lineage-induced mesenchymal stem cells into a host from which they have originated for purposes of mesenchymal tissue regeneration or repair.

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Young et al., J. Cell. Biochem., Suppl 0 (16 Part F): 136, Abstract CE 307 (1992).
Lennon et al., Exp. Cell Res., 219(1):211-22 (1995).

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