LIM mineralization protein splice variants

Details LIM mineralization protein splice variants LIM mineralization protein splice variants

2006-05-16

2006-05-16

Nguyen, Dave Trong (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07045614

ABSTRACT:
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding splice variants of LIM mineralization protein. The transfection may occur ex vivo or in vivo by direct injection of virus or naked plasmid DNA. In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention.

REFERENCES:
patent: WO 99/06563 (1999-02-01), None
Boden, et al., 1998, Endocrinology, 139: 5125-5134.
Kitty et al. 1999, Eur. J. Biochem., 266: 83-93.
Olsen et al., 1999, Molecular Brain Research, 64: 255-263.
Y. Liu et al., “BMP-6 Induces a Novel Lim Protein Involved in Bone Mineralization and Osteocalcin Secretion”, Juornal of Bone and Mineral Research, NY, US, 12:49 (Aug. 1, 1997).
D.M. Kingsley, “What Do BMPs Do in Mammals? Cluses From the Mouse Short-Ear Mutation”, TIG, vol. 10, No. 1, Jan. 1994.
S.D. Boden et al., “LMP-1, A Lim-Domain Protein, Mediates BMP-6 Effects on Bone Formation”, Endocrinology, vol. 139, No. 12, pp. 5125-5134, May 1998.
B.L.M. Hogan, “Bone Morphogenetic Proteins: Multifunctional Regulators of Vertebrate Development”, Genes and Development, vol. 10, pp. 1580-1594, 1996.

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