LIL-Stat DNA binding sites and methods for identifying inhibitor

Chemistry: analytical and immunological testing – Process or composition for determination of physical state... – Corrosion resistance or power

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4351723, 536 231, 536 241, C12Q 168, C07H 2100, C07H 2104

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058210539

ABSTRACT:
A method for finding an agent which inhibits interaction between LIL-Stat protein and a nucleic acid having a LIL-Stat binding sequence is described. The LIL-Stat protein is contacted with the nucleic acid in the presence of an agent which inhibits or does not inhibit the interaction between the LIL-Stat protein and the nucleic acid. It is determined whether or not the agent inhibits this interaction. Also described are a method for treating an inflammatory response in a mammal, a therapeutic inhibitory agent suitable for treating or preventing an inflammatory response in a mammal, and DNA molecules having a DNA sequence encoding a binding site for the LIL-Stat protein.

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