Lignosulfonate based pharmacologic agent with anti-coagulant and

Chemistry: natural resins or derivatives; peptides or proteins; – Lignins or derivatives – Compound containing nitrogen attached directly or indirectly...

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162 16, 4241951, 514 22, C07G 100, A61K 3170

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active

049887998

ABSTRACT:
A lignosulfonate useful pharmacologically as an anti-thrombotic that inhibits deep venous thrombophlebitis without effecting blood coagulation, and which causes no apparent increased bleeding or side effects. The lignosulfonate is isolated from softwood spent sulfite liquor, and is administered in low dosages of from about 0.05 to about 1.0 mg/milliter of blood. A method of making and administering the lignosulfonate is also disclosed.

REFERENCES:
patent: Re24213 (1956-09-01), Van Blaricom et al.
patent: 2710254 (1955-06-01), Van Blaricom et al.
patent: 3297676 (1967-01-01), Brauns
patent: 4562236 (1985-12-01), Lin
patent: 4748235 (1988-05-01), Dilling et al.
Loomis et al., "Heparin-like Anticoagulant Action of Sulfonated Lignins from Commercial Waste Sulfite Liquor", Journal of Pharmacology and Experimental Therapeutics, vol. 109, pp. 21-25, 1953.

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