Lignan analogues, methods of preparation thereof and anti-hyperl

Details Lignan analogues, methods of preparation thereof and anti-hyperl Lignan analogues, methods of preparation thereof and anti-hyperl

1994-09-07

1995-09-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6976

Patent

active

054498147

ABSTRACT:
An anti-hyperlipemic agent which has a potent activity of reducing LDL and VLDL cholesterols, which are thought to be a risk factor for arteriosclerosis among total blood cholesterols, and which is excellent in the antioxidant activity on LDL, is provided. Additionally, a compound and a pharmaceutically acceptable salt thereof are disclosed, which is represented by Formula (I): ##STR1## [wherein R.sup.1 is a lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl or aralkyl group which is optionally substituted; R.sup.2 is a group represented by the formula: --COOR' (wherein R' is a lower alkyl or aralkyl which is optionally substituted), lower alkyl or halogenated lower alkyl; or R.sup.1 and R.sup.2, together with adjacent carbonyl group, form a cyclohexanone ring represented by the formula: ##STR2## R.sup.3 is a phenyl group optionally being substituted, and, ring A is a benzene nucleus which is optionally substituted, or a heterocyclic ring containing S or O optionally being substituted].

REFERENCES:
patent: 4771072 (1988-09-01), Iwasaki et al.
patent: 4840951 (1989-06-01), Iwasaki et al.
Broom et al., "A General Route to Substituted Naphthols", J. C. S. Chem. Comm., 1978, pp. 162-164.

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