Light sensitive liposomes

Details Light sensitive liposomes Light sensitive liposomes

1986-11-05

1989-11-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, 264 46, 4284022, A61K 3722, A61J 500, B01J 1302, B32B 516

Patent

active

048821659

ABSTRACT:
Light sensitive liposomes are provided which release their contents on demand in response to irradiation with an appropriate wavelength of light. Substantially all the liposome contents can be released within about 60 seconds.
Preferred embodiments of the light sensitive liposomes include lipids having at least one retinoyl group and being a structural component of the lipid membrane.

REFERENCES:
patent: 3993754 (1976-11-01), Rahmam et al.
patent: 4016290 (1977-04-01), Rahman
patent: 4199565 (1980-04-01), Fullerton
patent: 4235871 (1980-11-01), Papahadjoporlos
patent: 4241046 (1980-12-01), Papahadjopoulos
patent: 4331654 (1982-05-01), Morris
patent: 4356167 (1982-10-01), Kelly
Pidgeon, C. and Hunt, C. A., "Photosomes: Light Sensitive Liposomes", p. 88 of Abstracts published by the American Pharmaceutical Assoc. on Sep.-Oct., 1980.
Delmelle, M., Photochem. Photobiol., 28:357-360 (1978).
Warner et al., J. Lipid Research, 18, pp. 548-551 (1977).
Patel et al., J. Lipid Research, 20, pp. 674-677 (1979).
Kremer et al., Biochem., 16, No. 17, pp. 3932-3935 (1977).
Hellingwerf et al., Biochimica Biophysica Acta, 547, pp. 544-582 (1979).
Delwelle, Protochem Photobiol, 28:357-360 (1978).
CA 95:49342p .alpha.Tocopherol Retards Auto Oxidation and Prolongs Shelf Life of Liposomes.

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