Light scattering immunoassay involving particles with selective

Details Light scattering immunoassay involving particles with selective Light scattering immunoassay involving particles with selective

1982-04-15

1984-05-01

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

250574, 356341, 422 73, 436517, 436533, 436537, 436805, 436807, 436817, G01N 3354, G01N 2149

Patent

active

044462395

ABSTRACT:
A technique for measuring the degree of an antigen-antibody reaction by preparing a suspension of insoluble microscopic carrier particles of at least one type carrying an antigen, an antibody or a hapten, forming an agglutination promoting or inhibiting reaction system among the insoluble carrier particles based on an antigen-antibody reaction using the suspension and one or more antigen, antibody or hapten, irradiating the solution of the reaction system with laser light and detecting the light scattered from the reaction system at one or more specific angles, detecting a signal indicative of one or more specific frequency bands from the resulting scatter spectrum, and thenceforth calculating the quantity of antigen, antibody or hapten in a specimen on the basis of the detected signal. The intensity spectrum output of filter 11 for frequency band selection is in the form of a square root and is converted into the original intensity spectrum by means of a squaring circuit 12. The output of the squaring circuit is recorded by a recorder 10.

REFERENCES:
patent: 4080264 (1978-03-01), Cohen
patent: 4174952 (1979-11-01), Cannell
patent: 4204837 (1980-05-01), Sternberg
patent: 4213764 (1980-07-01), O'Connor
patent: 4224304 (1980-09-01), Sawai
patent: 4268171 (1981-05-01), Sternberg
patent: 4401387 (1983-08-01), Tokinage
S. B. Dubin et al., Proc. N.A.S., vol. 57, 1164-1171 (1967).
G. K. Von Schulthess et al., Molecular Immunology, 17, 81-92 (1980).

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