Light-force sensor and method for measuring axial...

Optics: measuring and testing – By particle light scattering – With photocell detection

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C356S343000, C250S251000

Reexamination Certificate

active

07133132

ABSTRACT:
An optical trap and method for measuring both transverse and longitudinal forces on a trapped particle. Laser light sources generate first and second light beams that are focused to the trap region in a counter-propagating manner for trapping the particle. Detectors measure changes in power deflections of the light beams leaving the trap region, and changes in power concentrations of the light beams leaving the trap region. A processor calculates the transverse forces on the particle based upon the measured changes in the power deflections of the light beams, and calculates the longitudinal forces on the particle based upon the measured changes in the power concentrations of the light beams. A single beam optical trap and method are also disclosed, where the second optical beam is generated by a reflection of the first optical beam off of the trapped particle.

REFERENCES:
patent: 4512036 (1985-04-01), Laor
patent: 4927268 (1990-05-01), Carr et al.
patent: 5079169 (1992-01-01), Chu et al.
patent: 6137105 (2000-10-01), Drobot et al.
patent: 6744038 (2004-06-01), Wang et al.
patent: 6778724 (2004-08-01), Wang et al.
patent: 6785437 (2004-08-01), Hagood et al.
patent: 6806464 (2004-10-01), Stowers et al.
patent: 6850363 (2005-02-01), Wendenburg et al.
patent: 6975785 (2005-12-01), Ghandi et al.
patent: 2002/0121443 (2002-09-01), O'Connell
patent: 2004/0248167 (2004-12-01), Quake et al.
patent: 2005/0157291 (2005-07-01), Bustamante et al.
Grange, Wilfried et al., “Optical Tweezers System Measuring The Change In Light Momentum Flux”, Rev. Sci. Instrum., vol. 73, No. 6, pp. 2308-2316, Jun. 2002.
Allersma, Miriam W. et al., “Two-Dimensional Tracking Of ncd Motility By Back Focal Plane Interferometry”, Biophysical Journal, vol. 74, Feb. 1998, pp. 1074-1085.
Massari, Nicola et al., “High Speed Digital CMOS 2D Optical Position Sensitive Detector”, European Solid State Circuit Conference (ESSCIRC) in 2002, pp. 723-726.
Svoboda and Block, Annu. Rev. Biophys. Biomol. Struct. vol. 23, pp. 247-285 (1994).
Hamamatsu Profile Sensor S9132 Preliminary Data Sheet, Jan. 2004, pp. 29-30.
Universitat Leipzip, “Optical Forces”, Physik Weicher Materie, 6 pages.
Smith, Steven B. et al., “Optical-Trap Force Transducer That Operates By Direct Measurement Of Light Momentum”, Methods In Enzymology, vol. 361, Elsevier Science, 2003, pp. 134-163.
Smith, Steven B. et al., “Overstretching B-DNA: The Elastic Response Of Individual Double-Stranded And Single-Standard DNA Molecules”, Science, vol. 271, pp. 795-798, Feb. 9, 1996.
Kellermayer, Miklos S., et al., “Folding-Unfolding Transitions In Single Titin Molecules Characterized With Lazer Tweezers”, Science, vol. 276, May 16, 1997, pp. 1112-1116.
Buican, T.N., “Automated Cell Separation Techniques Based On Optical Trapping”, Cell Separation Science And Technology, Ch. 4 American Chemical Society, 1991, pp. 59-72.
Ghislain, Lucien P., et al., “Measurement Of Small Forces Using An Optical Trap”, Rev. Sci. Instrum., 65(9), Sep. 1994, pp. 2762-2768.
Bryant Zev et al., “Structural Transitions And Elasticity From Torque Measurements On DNA”, Nature, vol. 424, Jul. 17 2003, pp. 338-341.
Bustamante, Carlos, et al., “Ten Years Of Tension: Single-Molecule DNA Mechanics”, Nature, vol. 421, Jan. 23, 2004, pp. 423-427.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Light-force sensor and method for measuring axial... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Light-force sensor and method for measuring axial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Light-force sensor and method for measuring axial... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3621161

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.