Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2011-04-05
2011-04-05
Gabel, Gailene R (Department: 1641)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069800, C530S356000, C530S387300
Reexamination Certificate
active
07919274
ABSTRACT:
Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.
REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4540564 (1985-09-01), Bodor
patent: 5166320 (1992-11-01), Wu et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5389623 (1995-02-01), Bodor
patent: 5543396 (1996-08-01), Powers et al.
patent: 5650135 (1997-07-01), Contag et al.
patent: 5683888 (1997-11-01), Campbell
patent: 5726025 (1998-03-01), Kirschner et al.
patent: 5882914 (1999-03-01), Semenza
patent: 5925558 (1999-07-01), Tsien et al.
patent: 5958713 (1999-09-01), Thastrup et al.
patent: 6090786 (2000-07-01), Augustyns et al.
patent: 6217847 (2001-04-01), Contag et al.
patent: 6222018 (2001-04-01), Semenza
patent: 6243980 (2001-06-01), Bronstein et al.
patent: 6376257 (2002-04-01), Persechini
patent: 6428978 (2002-08-01), Olsen et al.
patent: 6436654 (2002-08-01), Berkenstam et al.
patent: 6566088 (2003-05-01), McKnight et al.
patent: 6610494 (2003-08-01), Marquardt et al.
patent: 6849718 (2005-02-01), Kaelin et al.
patent: 6855510 (2005-02-01), Kaelin et al.
patent: 7053046 (2006-05-01), McGrath
patent: 7176345 (2007-02-01), Kaelin, Jr. et al.
patent: 7361463 (2008-04-01), Kaelin, Jr. et al.
patent: 2004/0248233 (2004-12-01), Kaelin, Jr. et al.
patent: 2005/0186650 (2005-08-01), Kaelin, Jr. et al.
patent: WO 87/03304 (1987-06-01), None
patent: WO 00/71565 (2000-11-01), None
patent: WO 0069908 (2000-11-01), None
patent: WO 0074725 (2000-12-01), None
Eftink, M.R. Fluorescence methods for studying equilibrium macromolecule-ligand interactions. Methods Enzymol. 1997;278:221-257.
Du, H., et al. Isolation of the protein backbone of an arabinogalactan-protein from the styles ofNicotiana alataand characterization of a corresponding cDNA. Plant Cell. 1994;6:1643-1653.
Chang, K.H., et al. Acyl-adenylate motif of the acyl-adenylate/thioester-forming enzyme superfamily: A site-directed mutagenesis study with thePseudomonassp. strain CBS3 4-chlorobenzoate:coenzyme A ligase. Biochemistry. 1997;36:15650-15659.
Blum, L.J. & Coulet, P.R. Atypical kinetics of immobilized firefly luciferase. Biotechnol. Bioeng. 1986;28:1154-1158.
Krek (VHL takes HIF's breath away, Nature Cell Biology 2: E121-E123 (Jul. 2000).
GenBank Accession No. Q1665 (Oct. 16, 2001), Pubmed Entry Only.
Semenza,Annu Rev Cell Dev Biol15, 551-578 (1999).
Wenger,J Exper Biol203, 1253-1263 (2000).
Semenza,Cell98, 281-4 (1999).
Zhu and Bunn,Resp Phys115, 239-247 (1999).
Maher and. Kaelin,Medicine76, 381-91 (1997).
Tyers and Rottapel,Proc Natl Acad Sci USAOct. 26, 1999;96(22):12230-2 (1999).
Krek,Natl Cell BiolJul. 2000;2(7):E121-3 (2000).
Stebbins et al.,Science284, 455-461 (1999).
Ohh et al.,Nature Cell Biology2, 423-427 (2000).
Kamura et al.,Proc Natl Acad Sci USA97, 10430-10435 (2000).
Cockman et al.,J Biol Chem275, 25733-41 (2000).
Tanimoto et al.,EMBO J19, 4298-4309 (2000).
Maxwell et al.,Nature399, 271-5 (1999).
Goldberg et al.,Science242, 1412-1415 (1988).
Wang and Semenza.,Blood82, 3610-5 (1993).
Ho and Bunn,Biochem Biophys Res CommunJun. 5, 1996;223(1):175-80 (1996).
Chowdary et al.;Mol Cell Biol14, 1997-2003 (1994).
Huang et al.,Proc Natl Acad Sci USA95, 7987-92 (1998).
Pugh et al.,J Biol Chem272, 11205-14 (1997).
Srinivas et al.,Biochem Biophys Res Commun260, 557-61 (1999).
Kivirikko et al., MatrixBiology16, 357-368 (1998).
Winter and Page,Mol Cell Biol20, 4084-4093 (2000).
Friedman et al.,Proc Natl Acad Sci USA97, 4736-41 (2000).
Iliopoulos et al.,Nature Medicine1, 822-826 (1995).
Deshaies,Annu Rev Cell Dev Biol15, 435-67 (1999).
Takahashi et al.,J Biol Chem275, 14139-46 (2000).
Huang et al.,J Biol Chem274, 9038-44 (1999).
Liu et al.,J Biol Chem273, 15257-62 (1998).
Morita and Kourembanas,J Clin Invest96, 2676-82 (1995).
Sutter et al.,Proc Natl Acad Sci USA97, 4748-53 (2000).
Wang et al.,Biochem Biophys Res CommunNov. 13, 1995;216(2):669-75 (1995).
Sogawa et al.,Proc Natl Acad Sci USAJun. 23, 1998;95(13):7368-73 (1998).
Salceda et al.,Kidney IntFeb. 1997;51(2):556-9 (1997).
Wingrove and O'Farrell.,CellJul. 9, 1999;98(1):105-14 (1999).
Palmer et al.,Am J Physiol274, L212-9 (1998).
Melillo et al.,J Exp MedDec. 1, 1995;182(6):1683-93 (1995).
Bickel et al.,Hepatology28, 404-11 (1998).
Franklin et al.,Biochem J353, 333-338 (2001).
Adams et al.,Mol Cell Biol16, 6623-6633 (1996).
Adams et al.,Mol Cell Biol19, 1068-1080 (1999).
Akoulitchev et al.,Nature, 407,102-6 (2000).
Bagby et al.,Cell82, 857-867 (1995).
Bandara et al.,Nature352, 249-251 (1991).
Beijersbergen et al.,Genes Dev9, 1340-1353 (1995).
Bieniasz et al.,Proc Natl Acad Sci USA96, 7791-7796 (1999).
Bochar et al.,J. Biol Chem274, 13162-13166 (1999).
Chen et al.,Mol Cell Biol7, 2745-2752 (1987).
Chen et al.,Mol Cell Biol16, 4673-4682 (1996).
Dahmus,J Biol Chem271, 19009-19012 (1996).
Devoto et al.,Cell68, 167-176 (1992).
Dynlacht,Nature389, 149-152 (1997).
Dynlacht et al.,Proc Natl Acad Sci USA91, 6359-6363 (1994).
Dynlacht et al.,Mol Cell Biol17, 3867-3875 (1997).
Ewen et al.,Science255, 85-87 (1992).
Faha et al.,Science255, 87-90 (1992).
Felzen et al.,Mol Cell Biol19, 4241-4246 (1999).
Fu et al.,J Biol Chem274, 34527-34530 (1999).
Gebara et al.,J Cell Biochem64, 390-402 (1997).
Gossen et al.,Proc Natl Acad Sci USA89, 5547-5551 (1992).
Hannon et al.,Genes Dev7, 2378-2391 (1993).
Hengartner et al.,Mol Cell2, 43-53 (1998).
Jackson et al.,J Cell Biol130, 755-69.
Jeffrey et al.,Science267, 1498-1502 (1995).
JonesGenes Dev11, 2593-2599 (1997).
Kaelin et al.,Cell64, 521-532 (1991).
Kimmelman et al.,Mol Cell Biol19, 4774-4787 (1999).
Krek et al.,Cell78, 161-72 (1994). (Abstract Only).
Lania et al.,J Cell Physiol179, 134-141 (1999).
Lee et al.,Genes Dev10, 1621-1632 (1996).
Lees et al.,Genes Dev6, 1874-1885 (1992).
Leresche et al.,Exp Cell Res229, 282-288 (1996).
Ma et al.,Genes Dev14, 2298-2313 (2000).
Majello et al.,Oncogene18, 4598-4605 (1999).
Mudryj et al.,Cell65, 1243-1253 (1991).
Neuman et al.,Mol Cell Biol17, 5338-47 (1997).
Noble et al.,Trends Biochem Sci22, 482-487 (1997).
Peeper et al.,EMBO J12, 1947-1954 (1993).
Perkins et al.,Science275, 523-527 (1997).
Qin et al.,Mol Biol Cell15, 742-755 (1995).
Rickert et al.,Oncogene18, 1093-1102 (1999).
Roberts,Cell98, 129-132 (1999).
Schulman et al.,Proc Natl Acad Sci USA95, 10453-10458 (1998).
Schwarz et al.,EMBO J12, 1013-1020 (1993).
Sellers et al.,Proc Natl Acad Sci USA92, 11544-11548 (1995).
Shanahan et al.,Mol Cell Biol19, 1460-1469 (1999).
Sherr,Science274, 1672-1677 (1996).
Smith et al.,Cell Growth Differ9, 297-303 (1998).
Starostik et al.,Mol Cell Biol16, 3606-3614 (1996).
Tedder et al.,J Immunology143, 712-717 (1989).
van den Heuvel and Harlow,Science262, 2050-2053 (1993).
Weinberg,Cell81, 323-330 (1995).
Xu et al.,Mol Cell Biol14, 8420-8431 (1994).
Yankulov et al.,EMBO J16, 1638-1646 (1997).
Zamanian et al.,Mol Biol Cell4, 389-396 (1993).
Zhao et al.,Genes Dev12, 456-461 (1998).
Zhao et al.,Genes and Dev14, 2283-2297 (2000).
Zhu et al.,EMBO J14, 1904-1913 (1995a).
Zhu et al.,Genes Dev9, 1740-1752 (1995b).
Zhu et al.,Genes Dev11, 2622-2632 (1997).
Zwijsen et al.,Cell88, 405-15 (1997).
Zwijsen et al.,Genes Dev12, 3488-98 (1998).
Nicole, et al.,Biochem. Biophys. Res. Comm., 276:654-659 (2000).
Parker, et al.,Mol. Brain Res., 77:199-208 (2000).
Wittenmayer, et al.,Eur. J. Biochem., 267:5247-5256 (2000).
International Search Report for PCT/US03/35154, mailing date: May 11, 2004.
D'Angelo et al.J. Biol. Chem., 278(17):15406-15411 (2003).
Day R.N.Mol. Endocrinol., 12(9):1410-1419 (1998).
Fukumura et al.Cancer Res., 61(16):6020-6024 (2001).
Pacheco et al.Gene, 242(1-2):249-256 (2000).
In
Kaelin, Jr. William G.
Kim Tae-You
Livingston David M.
Dana-Farber Cancer Institute Inc.
Elrifi Ivor R.
Gabel Gailene R
Kozakiewicz Cynthia A.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
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