Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-09-06
2010-11-09
Babic, Christopher M. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07829275
ABSTRACT:
A method of detecting the presence of an analyte, such as a target nucleic acid sequence, protein sequence or small molecule, which can also be employed to detect the formation of duplex structures, is disclosed. The method can comprise nucleic acids, proteins and small molecules, employing photoelectrochemically active nanoparticles, branched polymers or other structures that carry photoelectrochemically active molecules capable of generating a photocurrent when excited by light in the presence of an electric field is disclosed. The method can be employed to detect hybridization on an array and can be employed in sequencing, mutational analysis (for example, single nucleotide polymorphisms and other variations in a population) and for monitoring gene expression by analysis of the level of expression of messenger RNA extracted from a cell. The method is applicable to the detection of antibody binding or other protein binding for analyte detection in an array format. The creation of an array addressable by light is disclosed.
REFERENCES:
patent: 3607691 (1971-09-01), Goldberg et al.
patent: 4851331 (1989-07-01), Vary et al.
patent: 5082627 (1992-01-01), Stanbro
patent: 5185243 (1993-02-01), Ullman et al.
patent: 5200313 (1993-04-01), Carrico
patent: 5277782 (1994-01-01), DuPree et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5420419 (1995-05-01), Wood
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5483068 (1996-01-01), Moulton et al.
patent: 5489776 (1996-02-01), Lung
patent: 5503728 (1996-04-01), Kaneko et al.
patent: 5503980 (1996-04-01), Cantor
patent: 5528035 (1996-06-01), Masarik
patent: 5573907 (1996-11-01), Carrino et al.
patent: 5669979 (1997-09-01), Elliott et al.
patent: 5679524 (1997-10-01), Nikiforov et al.
patent: 5770369 (1998-06-01), Meade et al.
patent: 5866336 (1999-02-01), Nazarenko et al.
patent: 5874046 (1999-02-01), Megerle
patent: 5922537 (1999-07-01), Ewart et al.
patent: 5952172 (1999-09-01), Meade et al.
patent: 6004755 (1999-12-01), Wang
patent: 6027893 (2000-02-01), Orum et al.
patent: 6046038 (2000-04-01), Nilsen
patent: 6051378 (2000-04-01), Monforte et al.
patent: 6063573 (2000-05-01), Kayyem
patent: 6066457 (2000-05-01), Hampson et al.
patent: 6090933 (2000-07-01), Kayyem et al.
patent: 6127127 (2000-10-01), Eckhardt et al.
patent: 6144031 (2000-11-01), Herring et al.
patent: 6171793 (2001-01-01), Phillips et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6265155 (2001-07-01), Meade et al.
patent: 6291188 (2001-09-01), Meade et al.
patent: 6301038 (2001-10-01), Fitzmaurice et al.
patent: 6355491 (2002-03-01), Zhou et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6361994 (2002-03-01), Hudson et al.
patent: 6403317 (2002-06-01), Anderson
patent: 6503711 (2003-01-01), Krull et al.
patent: 6506564 (2003-01-01), Mirkin et al.
patent: 6541617 (2003-04-01), Bamdad et al.
patent: 6589737 (2003-07-01), Gruber et al.
patent: 6589742 (2003-07-01), Edman et al.
patent: 2002/0094526 (2002-07-01), Bayley et al.
patent: 2002/0103517 (2002-08-01), West et al.
patent: 2002/0119455 (2002-08-01), Chan
patent: 2002/0127574 (2002-09-01), Mirkin et al.
patent: 2002/0160195 (2002-10-01), Halas et al.
patent: 2003/0003300 (2003-01-01), Korgel et al.
patent: 2003/0034486 (2003-02-01), Korgel
patent: 2003/0044805 (2003-03-01), Mirkin et al.
patent: 2003/0077625 (2003-04-01), Hutchison
patent: 2004/0053222 (2004-03-01), Storhoff et al.
patent: 2004/0180369 (2004-09-01), Franzen et al.
patent: 2005/0191651 (2005-09-01), Franzen et al.
patent: 2006/0094860 (2006-05-01), Take
patent: 2006/0099146 (2006-05-01), Chow et al.
patent: 2006/0099148 (2006-05-01), Fisher et al.
patent: 2006/0286570 (2006-12-01), Rowlen et al.
patent: 2007/0009954 (2007-01-01), Wang et al.
patent: 2007/0031829 (2007-02-01), Yasuno et al.
patent: 2007/0042400 (2007-02-01), Choi et al.
patent: 2007/0042419 (2007-02-01), Barany et al.
patent: 2010/0000881 (2010-01-01), Franzen et al.
patent: WO94/21820 (1994-09-01), None
patent: WO96/41011 (1996-12-01), None
patent: WO97/31256 (1997-08-01), None
patent: WO98/04740 (1998-02-01), None
patent: WO 98/39352 (1998-09-01), None
patent: WO99/51778 (1999-10-01), None
patent: WO 01/00876 (2000-06-01), None
patent: WO03/062783 (2003-01-01), None
patent: WO2005/042785 (2005-05-01), None
Willner et al. (“Photoelectrochemistry with Controlled DNA-Cross-Linked CdS Nanoparticle Arrays” Agnew Chem Int Ed Engl. May 18, 2001. 40(10), pp. 1861-1864).
Drouard et al. (“CdS nanoparticle-modified electrodes for photoelectrochemical studies” Chemical Communications. 1999. pp. 67-68).
Steel et al. (“Electrochemical Quantitation of DNA Immobilized on Gold” Analytical Chemistry. 1998. vol. 70, No. 22: pp. 4670-4677).
Drouard et al. (“CdS nanoparticle-modified electrodes for photoelectrochemical studies” Chemical Communications. 1999. pp. 67-68).
Steel et al. (“Electrochemical Quantitation of DNA Immobilized on Gold” Analytical Chemistry. 1998. vol. 70, No. 22: pp. 4670-4677).
Drouard et al. (“CdS nanoparticle-modified electrodes for photoelectrochemical studies” Chemical Communications. 1999. pp. 67-68).
Steel et al. (“Electrochemical Quantitation of DNA Immobilized on Gold” Analytical Chemistry. 1998. vol. 70, No. 22: pp. 4670-4677).
Microarray Biochip Technology, (entire book) 2000.
Microarrays and Related Technologies: Miniaturation and Acceleration of Genomic Research, Report 8, May 2001Cambridge Healthtech Institute's Genomic Reports Series.
Duggan et al.,Expression profiling using cDNA microarrays, Nature Genomics21:10-14 (Jan. 1999).
Cheung etal.,Making and reading microarrays, Nature Genomics21:15-19 (Jan. 1999).
Lipshutz et al.,High density synthetic oligonucleotide arrays, Nature Genomics21:20-24 (Jan. 1999).
Bowtell,Options available—from start to finish—for obtaining expression data by microarray, Nature Genomics21:25-32 (Jan. 1999).
Brown, et al.,Exploring the new world of the genome with DNA microarrays, Nature Genomics21:33-37 (Jan. 1999).
Cole et al.,The genetics of cancer—a 3D model, Nature Genomics21:38-41 (Jan. 1999).
Hacia,Resequencing and mutational analysis using oligonucleotide microarrays, Nature Genomics21: 42-47 (Jan. 1999).
Debouck et al.,DNA microarrays in drug discovery and development, Nature Genomics21:48-50 (Jan. 1999).
Bassett, Jr., et al.,Gene expression informatics-it's all in your mine, Nature Genomics21:51-55 (Jan. 1999).
Chakravarti,Population genetics-making sense out of sequence, Nature Genomics21:56-60 (Jan. 1999).
Nuovo et al.,In Situ Amplication Using Universal Energy Transfer-labeled Primers, The J. Of Histochemistry&Cytochemistry47(3):273-279 (1999).
Pastinen et al.,Multiplex, fluorescent, solid-phase minisequencing for efficient screening of DNA sequence variation, Clinical Chemistry42(9):1391-1397(1996).
Dubiley et al.,Fractionation, phosphorylation and ligation on oligonucleotide microchips to enhance sequencing by hybridization, Nucleic Acids Research27(12):2259-2265 (1997).
Michael, et al.,Randomly Ordered Addressable High-Density Optical Sensor Arrays, Anal. Chem. 70:1242-1248 (1998).
Walt,Fiber Optic Imaging Sensors, Acc. Chem. Res. 31:267-278 (1998).
Lockhart, et al.,Expression monitoring by hybridization to high-density oligonucleotide arrays, Nature Biotechnology14:1675-1684 (Dec. 1996).
Pirrung,Spatially Addressable Combinatorial Libraries, Chem. Rev. 97:473-488 (1997).
Yershov et al.,DNA analysis and diagnostics on oligonucleotide microchips, Proc. Natl. Acad. Sci. USA93:4913-4918 (May 1996).
Taton et al.,Scanometric DNA Array Detection with Nanoparticle Probes, Science289:1757-1760 (Sep. 8, 2000).
Singh-Gasson et al.,Maskless fabrication of light-directed oligonuleotide microarrays using a digital micromirror array, Nature Biotechnology17-974-978 (Oct. 1999).
Beier et al.,Production by quantitative photolighograhic synthesis of individiually quality checked DNA microarrays, Nucleic Acids Research28(4):i-vi (2000).
Written Opinion from corresponding PCT patent applicat
Feldheim Daniel L.
Franzen Stefan
Babic Christopher M.
Jenkins Wilson Taylor & Hunt, P.A.
North Carolina State University
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