Ligands useful in radiographic imaging

Details Ligands useful in radiographic imaging Ligands useful in radiographic imaging

1994-06-07

1997-08-12

Wu, Shean C.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 165, 546334, 546336, 5462787, 5462821, 5462824, 5462834, 5462837, A61K 5100, A61K 732, C07D40102, C07D21170

Patent

active

056562535

ABSTRACT:
The present invention relates particularly to novel pyridine based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes, novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes, and amide-thiolate ligands having improved metal chelate formation kinetics. The amide-thiolate ligands include an amine which converts to a vinylogous amide upon complexation, thereby providing rapid complexation and thermodynamic stability. The ligands may be used for post formed labeling of biological substances for use in the fields of diagnosis and therapy.

REFERENCES:
patent: 4577042 (1986-03-01), Collins et al.
patent: 4965392 (1990-10-01), Fritzberg et al.
patent: 4988496 (1991-01-01), Srinivasan et al.
patent: 5202451 (1993-04-01), Fritzberg et al.
patent: 5310536 (1994-05-01), Srinivasan
patent: 5371184 (1994-12-01), Rajagopalan et al.
patent: 5382654 (1995-01-01), Lyle et al.
McOmie, "Protective Groups in Organic Chemistry", pp. 235-238, Plenium Press; (1973).
Hackh's "Chemical Dictionary", pp. 148, 388 (1983).
Lundeen, et al., "Sulfinato Coordination of Triplet-State . . . ". Inorg. Chem. 17(3), pp. 701-706 (1978).
Mueller, et al., "Pyridlalkyl amides", Chemical Abstract 105:226378c (1986).
Lomis, et al., "Effects of a thio group . . . ", Chemical Abstract 111:107960a (1986).
Fuller, "Acyclaminoalkylpyridineamides . . . ", Chemical Abstract 114:75196z (1986).
Handa, et al., "Synthesis, Properties . . . ", Chemical Abstract 110:87409b (1989).
Bryson, et al., "Protecting Groups in the preparation of thiolate complexes of Technetium", p. 2950, Inorg. Chem., vol. 29, No. 16 (1990).
McKenzie, "Complexes of binucleating ligands", p. 5616, Inorg. Chem., vol. 26, No. 21 (1987).

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