Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1998-08-28
2000-02-08
Saunders, David
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241351, 4241431, 4241521, 424 937, 435 11, 435325, 514 2, 530350, 530351, 5303871, 5303873, 5303882, A61K 39395, A01N 6300, A01N 3718, C07K 1628
Patent
active
060225408
ABSTRACT:
Disclosed are compositions and methods for accelerating the differentiation of human MSCs into the osteogenic lineage with resultant enhanced de novo bone formation. This makes possible improved methods for bone defect repair. Thus, one aspect of the invention is a method for accelerating the differentiation of ALCAM-bearing hMSCs into the osteogenic lineage by contacting such hMSCs with a ligand that binds to activated leukocyte-cell adhesion molecule (ALCAM) on a single hMSC. Preferably, the ligand is a F.sub.ab fragment of a monoclonal antibody expressed by the hybridoma of ATCC Accession No. HB 11789.
REFERENCES:
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5643736 (1997-07-01), Bruder et al.
Pittenger, et al., "Human Mesenchymal Stem Cells can be Directed into Chondrocytes, Adipocytes and Osteocytes," Abstract 1772, 6th International Congress on Cell Biology & 36th American Society for Cell Biology Annual Meeting, Dec. 7-11, 1996.
Bruder et al., "Growth Kinetics, Self-Renewal, and the Osteogenic Potential of Purified Human Mesenchymal Stem Cells During Extensive Subcultivation and Following Cyropreservation," Journal of Cellular Biochemistry, 64:278-294 (1997).
Haynesworth, et al., "Characterization of Cells with Osteogenic Potential from Human Marrow," Bone, 13:81-88 (1992).
Jaiswal, et al., "Osteogenic Differentiation of Purified Culture-Expanded Human Mesenchymal Stem Cells in Vitro," Journal of Cellular Biochemistry, 64:295-312 (1997).
Bowen, et al., "Cloning, Mapping, and Characterization of Activated Leukocyte-Cell Adhesion Molecule (ALCAM), a CD6 Ligand," :J. Exp. Med., 181:2213-2220 (1995).
Tanaka, et al., "Osteoblasts are Regulated by the Cellular Adhesion through ICAM-1 and VCAM-1," Journal of Bone and Mineral Research, 10(10):1462-1469 (1995).
Simmons and Torok-Storb, "Identification of Stromal Cell Precursors in Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1," Blood, 78(1):55-62 (1991).
Bruder and Caplan, "A Monoclonal Antibody Against the Surface of Osteoblasts Recognizes Alkaline Phosphatase Isoenzymes in Bone, Liver, Kidney, and Intestine," Bone, 11:133-139 (1990).
Bruder, et al., Monoclonal Antibodies Reactive with Human Osteogenic Cell Surface Antigens, Bone, 21(3):225-235 (1997).
Okazaki, et al., "Molecular Cloning and Characterization of OB-cadherin, a New Member of Cadherin Family Expressed in Osteoblasts," The Journal of Biological Chemistry, 269(16): 12092-12098 (1994).
Kadiyala, et al., "Culture Explanded Canine Mesenchymal Stem Cells Possess Osteochondrogenic Potential in Vivo and In Vitro," Cell Transplantation, 6(2):125-134 (1997).
Laessing, et al., "Molecular characterization of fish neurolin: a growth-associated cell surface protein and member of the immunoglobulin superfamily in the fish retinotectal system with Similarities to chick protein DM-GRASP/SC-1/BEN," Differentiation, 56:21-29 (1994).
Lee and Chuong, "Adhesion Molecules in Skeletogenesis: I. Transient Expression of Neural Cell Adhesion Molecules (NCAM) in Osteoblasts During Endochondral and Intramembranous Ossification," Journal of Bone and Mineral Research, 7(12): 1435-1446 (1992).
Resnick, et al., "The SRCR superfamily: a family reminiscent of the Ig superfamily," TIBS, 19:5-8 (1994).
Bruder, et al., "Monoclonal Antibodies Reactive with Human Osteogenic Cell Surface Antigens," Bone, 21(3):225-235 (1997).
Bruder Scott P.
Jaiswal Neelam
Olstein Elliot M.
Osiris Therapeutics, Inc.
Saunders David
VanderVegt F. Pierre
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