Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reissue Patent
2007-05-29
2009-11-17
Duffy, Patricia A (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C530S300000, C530S350000, C530S399000, C514S012200
Reissue Patent
active
RE040988
ABSTRACT:
Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.
REFERENCES:
patent: WO 96/34877 (1995-05-01), None
patent: WO 98/05352 (1997-08-01), None
Decision—Interlocutory Motions—Bd.R. 125(b),Bergsmav.Sutcliffe, Patent Interference No. 105,280, Paper 45, entered Apr. 18, 2006.
Redeclaration—Bd.R. 203(c),Bergsmav.Sutcliffe, Patent Interference No. 105,280, Paper No. 46, entered May 3, 2006.
Judgment—Bd.R. 127(b),Bergsmav.Sutcliffe, Patent Interference No. 105,280, Paper No. 62, filed Nov. 22, 2006.
Risold, et asl., “Preprohypocretin (Orexin) and Prolactin-Like Immunoreactivity are Coexpressed by Neurons of the Rat Lateral Hypothalamic Area,”Neuroscience Letters, 259: pp. 153-156 (1999).
Schachter, et al., “Prolactin mRNA Exists in Rat Hypothalamus,”Endocrinology, 114(5): pp. 1947-1949 (1984).
Valatx, et al,, “Mise en Evidence d'ARN Messagers de la Prolactine Apres Amplification Dans Le Cerveau Du Rat,”C.R. Acad. Sci. Paris, 315(3): pp. 295-301 (1992). (English Abstract Only).
Emanuele, et al., “The Rat Prolactin Gene is Expressed in Brain Tissue: Detection of Normal and Alternatively Spliced Prolactin Messenger RNA,”Molecular Endocrinology, 6: pp. 35-42 (1992).
Dutt, et al., “Prolactin, Central Nervous System and Behavior: A Critical Review,”Neuroendocrinology, 59: pp. 413-419 (1994).
De Lecea, et al., “The Hypocretins: Hypothalamus—Specific Peptides With Neuroexcitatory Activity,”Proc. Natl. Acad. Sci. USA, 95: pp. 322-327 (1998).
Grillon et al., “Alteration of Dynorphin and Secretogranin II in the Prolactin Immunoreactive Neurons of the Rat Lateral Hypothalamus Upon Osmotic Stimulation,”Neuroscience Letters, 208: pp. 33-36 (1996).
Fuxe, et al., “Prolactin-Like Immunoreactivity: Localization in Nerve Terminals of Rat Hypothalamus,”Science, 196: pp. 899-900 (1977).
Peyron, et al., “Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems,”The Journal of Neuroscience, 18(23): 9996-10015 (1998).
Alonso, et al., “Axons Containing a Prolactin-Like Peptide Project into the Perivascular Layer of the Median Eminence: An Immunocytochemical Light and Electron Microscope Study in Adult and Infant Rats,”Neuroendocrinology, 48: pp. 39-44 (1988).
Clapp, et al., “The Prolactin Gene is Expressed in the Hypothalmic-Neurohypophyseal System and the Protein is Processed into a 14-kDa Fragment with Activity like 16-kDa Prolactin,”Proc. Natl. Acad. Sci. USA, 91: pp. 10384-10388 (1994).
Griffond, et al., “Occurrence of Secretogranin II in the Prolactin-Immunoreactive Neurons of the Rat Lateral Hypothalamus: An In Situ Hybridization and Immunocy-tochemical Study,”Journal of Chemical Neuroanatomy, 9: pp. 113-119 (1995).
Paut-Pagano, et al., “Anatomical Distribution of Prolactin-Like Immunoreactivity in the Rat Brain,”Neuroendocrinology, 58: pp. 682-695 (1993).
Bahjaoui-Bouhaddi, et al., “Induction of Fos—Immunoreactivity in Prolactin-Like Containing Neurons of the Rat Lateral Hypothalamus After Insulin Treatment,”Neuroscience Letters, 168:11-15 (1994).
Griffond, et al., “Evidence for the Expression of Dynorphin Gene in the Prolactin—Immunoreactive Neurons of the Rat Lateral Hypothalamus,”Neuroscience Letters, 165: pp. 89-92 (1994).
Rudinger in Peptide Hormones, University Park Press, Baltimore Jun. 1976, pp. 1-7.
Lazar et al, Molecular and Cellular Biology, 8(3):1247-1255, 1988.
Burgas et al., The Journal of Cell Biology, 111:2129-2138, 1990.
Bergsma Derk J.
Yanigasawa Masahi
Duffy Patricia A
Han William T.
Lockenour Andrea V.
SmithKline Beecham Corporation
University of Texas Southwestern Medical Center at Dallas
LandOfFree
Ligands of the neuropeptide receptor HFGAN72 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ligands of the neuropeptide receptor HFGAN72, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligands of the neuropeptide receptor HFGAN72 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4137603