Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-05-11
1996-09-10
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4351721, 4352402, 4352523, 4353201, 530351, 530399, 536 235, 935 13, 424 851, C12N 1519, C07H 2104
Patent
active
055545122
ABSTRACT:
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancers.
REFERENCES:
patent: 5185438 (1993-02-01), Lemischka
J. G. Flanagan et al. Cell 63:185-194, 1990.
O. Rosnet et al. Oncogene 6:1641-1650, Sep. 1991.
Beckmann M. Patricia
Lyman Stewart D.
Immunex Corporation
Malaska Stephen L.
Spector Lorraine M.
Walsh Stephen G.
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