Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2008-09-08
2010-11-09
Steadman, David J (Department: 1656)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S007100, C702S027000
Reexamination Certificate
active
07829303
ABSTRACT:
The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity.
REFERENCES:
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6221645 (2001-04-01), Chrysler et al.
patent: 6225103 (2001-05-01), Keolsch et al.
patent: 6245884 (2001-06-01), Hook
patent: 6258386 (2001-07-01), Xia et al.
patent: 6268158 (2001-07-01), Pantoliano et al.
patent: 6291223 (2001-09-01), Christie et al.
patent: 6297021 (2001-10-01), Nienaber et al.
patent: 6329163 (2001-12-01), Anderson et al.
patent: 6420534 (2002-07-01), Gurney et al.
patent: 6440698 (2002-08-01), Gurney et al.
patent: 6545127 (2003-04-01), Tang et al.
patent: 6627739 (2003-09-01), Anderson et al.
patent: 7217556 (2007-05-01), Benson et al.
patent: 7384773 (2008-06-01), Benson et al.
patent: 7442537 (2008-10-01), Benson et al.
patent: 7524668 (2009-04-01), Benson et al.
patent: 7601528 (2009-10-01), Benson et al.
patent: 2001/0016324 (2001-08-01), Gurney et al.
patent: 2001/0018208 (2001-08-01), Gurney et al.
patent: 2001/0021391 (2001-09-01), Gurney et al.
patent: 2002/0037315 (2002-03-01), Gurney et al.
patent: 2002/0049303 (2002-04-01), Tang et al.
patent: 2002/0055459 (2002-05-01), Chopra et al.
patent: 2002/0064819 (2002-05-01), Gurney et al.
patent: 2002/0081634 (2002-06-01), Gurney et al.
patent: 2002/0115600 (2002-08-01), Keolsch et al.
patent: 2003/0095958 (2003-05-01), Bhisetti et al.
patent: 2004/0014194 (2004-01-01), Beyer et al.
patent: 2006/0136141 (2006-06-01), Benson et al.
patent: 2008/0201123 (2008-08-01), Cosgrove
patent: 2008/0215249 (2008-09-01), Benson et al.
patent: 2009/0125259 (2009-05-01), Nicholls et al.
patent: 2009/0170128 (2009-07-01), Benson et al.
patent: WO 00/17369 (2000-03-01), None
patent: WO 01/00663 (2001-01-01), None
patent: WO 01/00665 (2001-01-01), None
patent: WO 01/49097 (2001-07-01), None
patent: WO 01/49098 (2001-07-01), None
patent: WO 01/50829 (2001-07-01), None
patent: WO 02/25276 (2002-03-01), None
patent: WO 01/23533 (2002-04-01), None
patent: WO 02/053594 (2002-07-01), None
patent: WO 03/012089 (2003-02-01), None
McPherson et al., Eur. J. Biochem. 189:1-23, 1990.
Kierzek et al., Biophys Chem 91:1-20, 2001.
Nienaber et al., Nat. Biotechnol. 18:1105-1108, 2000.
Alvares et al., “Rat urate oxidase produced by recombinant baculovirus expression: formation of peroxisome crystalloid core-like structures”, Jun. 1992 Proceedings of the National Academy of Sciences USA vol. 89: pp. 4908-4912.
Dealwis et al., “X-ray analysis at 2.0 Angstrom resolution of mouse submaxillary rennin complexed with a decapeptide inhibitor CH-66, based on the 4- 16 fragment of rat angiotensinogen”, Feb. 1994, Journal of Molecular Biology, vol. 236: pp. 342-360.
Giege et al., Crystallogenesis of Biological Macromolecules: Facts and Perspectives, Jul. 1994m /acta /crystallographic Section D., vol. 50:pp. 339-350.
Kervinen et al., “Toward a universal inhibitor of retroviral proteases: Comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV and EIAV”, Nov. 1998, Protein Science, Bol. 7: pp. 2314-2323.
Berman et al., “The Protein Data Bank,” Nucleic Acids Res. Jan. 1, 2000:28(1): 235-42.
Bartlett et al., “CAVEAT: a program to facilitate the structure-derived design of biologically active molecules,” Molecular Recognition: Chemical and Biological Problems, Royal Society of Chemistry, Special Pub No. 78:182-196 (1989).
Benson et al., “An enzyme-substrate complex involved in bacterial cell wall biosynthesis,” National Struct. Biolo. 1995 (8):644-53.
Blundell et al., Protein Crystallography, Academic Press, New York, NY; title page, publication page, and table of contents only, 8 pages (1976).
Bohm, “The computer program LUDI: a new method for the de novo design of enzyme inhibitors,” J Comput Aided Mol Des. 1992:6(1):61-78.
Branden et al., “introduction to protein structure,” Garland Publishing, Inc. , New York, NY 1999; Cover page, copyright page, and pp. 373-374.
Bruinzeel et al., “Recombinant insect cell expression and purification of human •-secretase (BACE-1) for X-ray crystallography,” Protein Expr. Pruif. Oct. 2002: 26(1):139-148.
Ehehalt et al., “Splice variants of the •-site APP-cleaving enzyme BACE1 in human brain and pancreas,” Biochem Biophys Res Commun. Apr. 26, 2002:293(1):30-37.
Drenth, “Principles of Protein X-ray Crystallograph,” Second Edition, 1994 Springer-Verlag New York, Inc. pp. 1-18.
Brunger, “X-PLOR: Version 3.1, a System for X-Ray Crystallography and NMR”, Yale University Press, New Haven & London, 1992; cover page, publication page and table of contents; 13 pages.
Brunger et al., “Slow-cooling protocols for crystallographic refinement by simulated annealing,” Acta Crystallogr A. Jul. 1, 1990:46(Pt 7): 585-93.
Collaborative Computational Project, No. 4, “The CCP4 suite: programs for protein crystallography” Acta Cryst. 1994:D50:760-3.
CNX: Crystallograph and NMR eXplorer datasheet, Accelrys Corporate Headquarters, San Diego, CA (2001). [retrieved Aug. 30, 2002 from the Internet: URL:http://www.accelrys.com 2 pgs.].
Eisen et al., “HOOK:A program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site,” Proteins. 1994;19(3):199-221.
Epps et al., “The ligand affinity of proteins measured by isothermal denaturation kinetics,” Anal Biochem. May 1, 2001;292(1):40-50.
Hussain et al., “Identification of novel aspartic protease (Asp 2) as •-secretase,” Mol Cell Neurosci. Dec. 1999;14(6):419-27.
Jiang et al, “Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures,” J Mol Biol. Oct. 14, 1994:243(1)100-15.
Kang et al., “The precursor of Alzheimer's disease amyloid a4 protein resembles a cell-surface receptor,” Nature. Feb. 19, 1987;325(6106):733-6.
Kitaguchi et al., “Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity,” Nature Feb. 11, 1988;331(6156):530-2.
Kuntz et al., “A geometric approach to macromolecule-ligand interactions,” J Mol Biol. Oct. 25, 1982:161(2):269-88.
Lattman, “Use of the Rotation and Translation Functions,” Meth. Enzymol. 1985;115:55-77.
Lauri et al., CAVVEAT: a program to facilitate the design of organic molecules, J. Comput. Aided Mol. Des 1994;8:51-66.
Lin et al., “Human aspartic protease memapsin 2 cleaves the •-secretase site of •-amyloid precursor protein,” Proc Natl Acad Sci USA Feb. 15, 2000;97(4):1456-60.
Mallender et al., “Characterization of recombinant, soluble beta-secretase from an insect cell expression system,” Mol Pharmacol Mar. 2001, 59(3):619-26.
Martin, “3D Database Searching in Drug Design,” J. Med Chem 1992;35:2145-2154.
Meng et al., “Automated Docking with Grid-Based Energy Evaluation,” J. Comp. Chem. 1992;13:505-524.
Miranker et al., “Functionality Maps of Binding Sites: A multiple Copy Simultaneous Search Method,” Proteins: Struct. Funct. Gen. 1991;11:29-34.
National Institutes of Health, “BLAST 2 Sequences,” [online} United States; retrieved Aug. 29, 2001 from the Internet: <URL:http://www.ncbi.nlm.nih.gov/gorf/bl2.html.> 1 pg.
Navaza, “AMoRe: an automated package for molecular replacement,” Acta Cryst. 1994; A50:157-163.
Nishibata et al., “Automatic Creation of Drug Candidate Structures Based on Receptor Structure. Starting Point for Artificial Lead Generation,” Tetrahedron. 1991;47:8985-90.
Noren et al., “A general method for site-specific incorporation of unnatural amino acids into protein,
Benson Timothy Earl
Prince Donald Bryan
Woods Daisy Danielle
Elan Pharmaceuticals Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
Steadman David J
LandOfFree
Ligand screening method using a crystal of beta secretase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ligand screening method using a crystal of beta secretase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligand screening method using a crystal of beta secretase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4252576