Ligand precursors for incorporation into peptides

Details Ligand precursors for incorporation into peptides Ligand precursors for incorporation into peptides

1995-06-06

1998-03-31

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530326, 530327, 530328, 530329, 530330, 530335, 530337, 560155, 560553, A61K 3803

Patent

active

057340110

ABSTRACT:
Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and .gamma.-aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase synthesis, depending upon the choice of protecting groups. Ligand synthesis may then be completed at a later time to produce N.sub.3 S, N.sub.2 S.sub.2, and EDTA type chelating agents.

REFERENCES:
patent: 4476050 (1984-10-01), Kitaura et al.
patent: 4868326 (1989-09-01), Bouchaudon et al.
Caplus Abstract No. 1976:59978(Tsuji et al.).
Chemical Abstract No. 111: 23232(b) to Bouchaudon et al.
Rosowsky et al., J. Org. Chem. vol. 54 No. 23 (1989) pp. 5551-5557.
Obeidi et al., Int. J. Pept. Prot. Res. vol. 35(1990) 215-218.

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