Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1996-09-05
1998-08-25
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530334, 530335, 530339, 530345, C07K 100
Patent
active
057984441
ABSTRACT:
Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and .gamma.-aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase synthesis, depending upon the choice of protecting groups. Ligand synthesis may then be completed at a later time to produce N.sub.3 S, N.sub.2 S.sub.2, and EDTA type chelating agents.
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R. Arya et al., "Rapid Synthesis and Introduction of a Protected EDTA-like Group during the Solid-Phase Assembly of Peptides", Bioconjugate Chem., 1991, vol. 1, pp. 323-326.
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Altman et al., "Ring Opening of N-Tosylhistamine with Di-t-butyl Pyrocarbonate: Synthesis of 1,2-Diamino-4-tosylaminobutane Dihydrochloride", Chem. Soc., Chem. Commun., 1985, pp. 1133-1134.
Kolodziejczyk, Int J Pept Prot Res. 39, 382, 1992.
Dunn T. Jeffrey
Srinivasan Ananthachari
Lukton David
Tsang Cecilia J.
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