Ligand growth factors that bind to the erbB-2 receptor protein a

Details Ligand growth factors that bind to the erbB-2 receptor protein a Ligand growth factors that bind to the erbB-2 receptor protein a

1993-07-26

1996-11-26

Kim, Ph.D., Kay K. A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435244, 530350, 530399, 514 21, C12N 138, C12N 526

Patent

active

055784828

ABSTRACT:
The present invention relates to erbB-2 ligands and functional derivatives thereof which are capable of binding to the erbB-2 oncogene product. The present invention further pertains to anti-ligand molecules capable of recognizing and binding to the erbB-2 ligand molecule and to screening assays for such ligands. The present invention additionally relates to uses for the erbB-2 ligand, the anti-ligand molecules and the screening assays.
A method for inhibiting the growth of adenocarcinoma cells in a human, which cells overexpress the oncogene erbB-2, which entails administering to said human an amount of a 30 kDa glycoprotein effective to inhibit the growth of said cells.

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