Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-08-26
2000-03-21
Kemmerer, Elizabeth
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530300, 530412, 530413, 530399, C07K 14475, C07K 1702, A61K 3818
Patent
active
060402903
ABSTRACT:
The present invention relates to erbB-2 ligands and functional derivatives thereof which are capable of binding to the erbB-2 oncogene product. The present invention further pertains to anti-ligand molecules capable of recognizing and binding to the erbB-2 ligand molecule and to screening assays for such ligands. The present invention additionally relates to uses for the erbB-2 ligand, the anti-ligand molecules and the screening assays. The present invention also pertains to a method for inhibiting the growth of adenocarcinoma cells.
REFERENCES:
patent: 4705677 (1987-11-01), Makari
patent: 4774321 (1988-09-01), Rosner et al.
patent: 4785079 (1988-11-01), Gospodarowicz et al.
patent: 4859609 (1989-08-01), Dull et al.
patent: 4933294 (1990-06-01), Waterfield et al.
patent: 4968603 (1990-11-01), Slamon et al.
patent: 5015571 (1991-05-01), Niman
patent: 5030565 (1991-07-01), Niman et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5115096 (1992-05-01), Shoyab
patent: 5155027 (1992-10-01), Sledziewski et al.
patent: 5183884 (1993-02-01), Kraus et al.
patent: 5288477 (1994-02-01), Bacus
patent: 5367060 (1994-11-01), Vandlen et al.
patent: 5578482 (1996-11-01), Lippman et al.
Derbin et al., Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumor effects in vivo, Oncogene, 2: 387-394, 1988.
Lupu et al., The role of erB-2 and its ligands in growth control of malignant breat epithelium, Princess Takamatsu Symposia, 22: 49-60, 1991.
Bacus et al., A ligand for the erbB-2 oncogene product (gp30) induces differentation of human breast cancer cells, Cell Growth Diff., 3(7): 401-411, Jul. 26, 1992.
Lupu, et al., Chemical Abstracts, 113:476 (1990) (Abst. 228667K) (Science (1990) 249:1552-1555).
Bacus, et al., "A Ligand For The erbB-2 Oncogene Product (gp30) Induces Differentiation of Human Breast Cancer Cells," Lab. Invest., 66:12A (1992) (Abstr. 60).
Bacus, et al., "A Ligand For the erbB-2 Oncogene Product (gp30) Induces Differentiation of Human Breast Cancer Cells," Proceedings of the American Assn. for Cancer Res., 33:365 (1992) (Abstr. 2181).
Beug, et al., "Production and Characterization of Antisera Specific for the erb-Portion of p75, the Presumptive Transforming Protein of Avian Erythroblastosis Virus," Virology (1981) 111:201-210.
Sherwin, et al., "High-Molecular-Weight Transforming Growth Factor Activity in the Urine of Patients with Disseminated Cancer," Cancer Research (1983) 43:403-407.
Ullrich, et al., "Human Epidermal Growth Factor Receptor cDNA Sequence and Aberrant Expression of the Amplified Gene in A431 Epidermoid Carcinoma Cells," Nature (1984) 309:418-425.
Schechter, et al., "The neu Oncogene: and erbB-2-Related Gene Encoding a 185,000-M.sub..GAMMA. Tumour Antigen," Nature (1984) 312:513-516.
Coussens, et al., "Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene," Science (1985) 230:1132-1139.
Bargmann, et al., "The neu Oncogene Encodes an Epidermal Growth Factor Receptor-Related Protein," Nature (1986) 319:226-230.
Yamamoto, et al., "Similarity of Protein Encoded By the Human C-erb-B-2 Gene to Epidermal Growth Factor Receptor," Nature (1986) 319:230-234.
Lippman, et al., "Autocrine and Paracrine Growth Regulation of Human Breast Cancer," Breast Cancer Research and Treatment (1986) 7:59-70.
Dickson, et al., "Characterization of Estrogen Responsive Transforming Activity in Human Breast Cancer Cell Lines," Cancer Research (1986) 46:1707-1713.
Gentry, et al., "Characterization of Site-Specific Antibodies to the erbB Gene Product and EGF Receptor: Inhibition of Tyrosine Kinase Activity," Virology (1986) 152:421-431.
Stromberg, et al., "Human A673 Cells Secrete High Molecular Weight EGF-Receptor Binding Growth Factors that Appear to be Immunologically Unrelated to EGF or TGF-.alpha.," Journal of Cellular Biochemistry (1986) 32:247-259.
Stern, et al., "Oncogenic Activation of p185neu Stimulates Tyrosine Phosphorylation In Vivo," Molecular and Cellular Biology (1988) 8:3969-3973.
King, et al., "EGF Binding To Its Receptor Triggers A Rapid Tyrosine Phosphorylation of the erbB-2 Protein in the Mammary Tumor Cell Line SK-BR-3," The EMBO Journal (1988) 7:1647-1651.
Lax, et al., "Chicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha," Mol. Cell. Biol. (1988) 8:1970-1978.
Stern, et al., "EGF-Stimulated Tyrosine Phosphorylation of p185neu:A Potential Model for Receptor Interactions," The EMBO Journal (1988) 7:995-1001.
Hudziak, et al., "p185.sup.HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor," Mol. Cell. Biol. (1989) 9:1165-1172.
Harsh, IV, et al., "Oncogene-Related Growth Factors and Growth Factor Receptors In Human Malignant Glioma-Derived Cell Lines," Journal of Neuro-Oncology (1989) 7:47-56.
Lee, et al., "HER2 Cytoplasmic Domain Generates Normal Mitogenic and Transforming Signals In a Chimeric Receptor," The EMBO Journal (1989) 8:167-173.
Schneider, et al., "Differential Expression of the c-erbB-3 Gene in Human Small Cell and Non-Small Cell Lung Cancer," Cancer Research (1989) 49:4968-4971.
Maguire, et al., "Distribution of neu(c-erbB-2) Protein in Human Skin," Journal of Investigative Dermatology (1989) 92:786-789.
Slamon, et al., Studies of the HER-2
eu Proto-oncogene in Human Breast and Ovarian Cancer, Science (1989) 244:707-712.
Yarden, et al., "Experimental Approaches to Hypothetical Hormones: Detection of a Candidate Ligand of the Neu Protooncogene," Proc. Natl. Acad. Sci., USA (1989) 86:3179-3183.
Falck, et al., "c-erbB-2 Oncogene Product Staining in Gastric Adenocarcinoma. An Immunohistochemical Study," Journal of Pathology (1989) 159:107-111.
Oda, et al., "DNA Ploidy Pattern and Amplification of ERBB and ERBB2 Genes in Human Gastric Carcinomas," Virchows Archiv B Cell Pathol. (1990) 58:273-277.
Petch, et al., "A Truncated, Secreted Form of the Epidermal Growth Factor Receptor Is Encoded by an Alternatively Spliced Transcript in Normal Rat Tissue," Mol. Cell. Biol. (1990) 10:2973-2982.
Lupu, et al., "Direct Interaction of a Ligand for the erbB2 Oncogene Product with the EGF Receptor and p185.sup.erbB2," Science (1990) 249:1552-5.
Yarden, Yosef, "Agonistic Antibodies Stimulate the Kinase Encoded by the neu Protooncogene in Living Cells But the Oncogenic Mutant Is Constitutively Active," Proc. Natl. Acad. Sci. USA (1990) 87:2569-2573.
Lin, et al., "Insulin and Epidermal Growth Factor Stimulate Phosphorylation of p185.sup.HER-2 In the Breast Carcinoma Cell Line, BT474," Molecular and Cellular Endocrinology (1990) 69:111-119.
Alper, et al., "The Presence of cerbB-2 Gene Product-Related Protein In Culture Medium Conditioned by Breast Cancer Cell Line SK-BR-3," Cell Growth & Differentiation (1990) 1:591-599.
Koskinen, et al., "Similar Early Gene Responses to Ligand-Activated EGFR and neu tyrosine kinases in NIH3T3 cells," Oncogene (1990) 5:615-618.
Shirahata, et al., "Ras and Neu oncogenes Reverse Serum Inhibition and Epidermal Growth Factor Dependence of Serum-Free Mouse Embryo Cells," Journal of Cellular Physiology (1990) 144:69-76.
Langton, et al., "An Antigen Immunologically Related to the External Domain of gp185 is Shed from Nude Mouse Tumors Overexpressing the c-erbB-2 (HER-2
eu) Oncogene," Cancer Research (1991) 51:2593-2598.
Maihle, et al., "Native Avian c-erbB gene expresses a Secreted Protein Product Corresponding to the Ligand-Binding Domain of the Receptor," Proc. Natl. Acad. Sci. USA (1991) 88:1825-1829.
Lupu, et al., "A Novel TGF.alpha.-Related Growth Factor Interacts Directly With EGF Receptor and erbB-2," Proceedings of the American Assn. for Cancer Res., vol. 31, 1990 (Abstr. 491).
Linsley, et al., "Detection of Larger Polypeptides Structurally and Functionally Related to Type I Transforming Growth Factor," Proc. Natl. Acad. Sci. USA (1985) 82:356-360.
Kokai, et al., "Phosphorylation Process Induced by Epidermal Growth Factor Alters the Oncogenic and Cellular neu (NGL) Gene Products,
Lippman Marc E.
Lupu Ruth
Georgetown University
Kaufman Claire M.
Kemmerer Elizabeth
LandOfFree
Ligand growth factor gp30 that binds to the erbB-2 receptor prot does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ligand growth factor gp30 that binds to the erbB-2 receptor prot, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligand growth factor gp30 that binds to the erbB-2 receptor prot will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-730424