Ligand gold bonding

Details Ligand gold bonding Ligand gold bonding

1990-12-05

1994-03-15

Stoll, Robert L.

Compositions

Preservative agents

Anti-corrosion

436525, 436805, 435975, 428403, 5303915, B01J 1300, G01N 33553, G01N 33532

Patent

active

052943690

ABSTRACT:
Gold sol coated with alkanethiols and alkanethiol derivatives, which provide groups on the sol available for the linking of binding moieties such as antibodies, antigens or ligands to the gold sol. Di- and tri-thiol compounds bound to gold sol also facilitate the adsorption of antibodies, antigens or ligands to the sol. The coating process, and test kits incorporating the coated sols are also included.

REFERENCES:
patent: 4313734 (1982-02-01), Leuvering
patent: 4859612 (1989-08-01), Cole et al.
patent: 4879220 (1989-11-01), Mrsny et al.
E. B. Troughton et al., "Monolayer Films Prepared by the Spontaneous Self-Assembly of Symmetrical and Unsymmetrical Diakyl Sulfides from Solution onto Gold Substrates: Structure, Properties, and Reactivity of Constituent Functional Groups", LANGMUIR, vol. 4, No. 2, pp. 364-385, 1988, USA.
M. D. Porter et al., "Spontaneously Organized Molecular Assemblies. 4. Structural Characterization of n-Alkyl Thiol Monolayers on Gold by Optical Ellipsometry, Infrared Spectroscopy, and Electrochemistry", J. Am. Chem. Soc., 1987, 109, pp. 3559-5568, USA.
C. D. Bain et al., "Molecular-Level Control over Surface Order in Self-Assembled Monolayer Films of Thiols on Gold", Science, vol. 240, Apr. 1, 1988, pp. 62-63, USA.
A. Ulman et al., "Packing and Molecular Orientation of Alkanethiol Monolayers on Gold Surfaces", Langmuir, vol. 5, pp. 1147-1152, 1989, USA.
J. Turkevich et al., "A Study of the Nucleation and Growth Processes in the Synthesis of Colloidal Gold", Disc. of the Farady Society, 11, pp. 55-74, 1951, USA.

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