Ligand for vascular endothelial growth factor receptor

Details Ligand for vascular endothelial growth factor receptor Ligand for vascular endothelial growth factor receptor

2006-09-26

2006-09-26

Andres, Janet L. (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C530S322000, C530S323000, C530S333000

Reexamination Certificate

active

07112654

ABSTRACT:
The present invention relates to compositions comprised of a peptide ligand or derivatives thereof that are capable of specific binding to the high affinity receptor-1 of vascular endothelial growth factor (VEGF) and structure similar receptors. The invention further provides a peptide ligand or derivatives thereof that are capable of inhibiting angiogenesis induced by VEGF. The present invention also provides a method for treatment or diagnosis of disease associated with angiogenesis in a patient in need of therapy comprising administering to the patient an effective amount of the pharmaceutical composition of the present invention and a pharmaceutical acceptable carrier.

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Ecklin, D.J., et al., “Monoclonal Anti-Vascular Endothelial Growth Factor (VEGF) Receptor (KDR) Antibodies Which are Inhibitors of VEGF Binding and Antagonists of VEGF-Stimulated Signaling and Growth of Human Endothelial Cells”, AACR, 39:96 (Mar. 1998).
Iro, Nobuyuki, Journal of Biological Chemistry, 273:23410-23418 (1998).

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