Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-07-30
2000-10-31
Mosher, Mary E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1447
Patent
active
061404675
ABSTRACT:
A novel ligand (p30) for herpes virus entry mediator, HVEM, is provided. p30 is useful for modulating immune responses and in inhibiting infection by herpes virus. Methods for treating subjects with lymphoid cell disorders or those having or suspected of having a herpes virus infection, utilizing p30 of the invention, are also provided.
REFERENCES:
Harrop et al, Journal of Interferon and Cytokine Research 18(5): A-39, abstract 2.02, May 1998.
Hsu et al, Journal of Interferon and Cytokine Research 18(5): A-40, abstract 2.04, May 1998.
Mauri et al, Immunity 8:21-30, Jan. 1998.
Huang et al., "Anti-idiotypic antibodies mimicking glycoprotein D of herpes simplex virus identify a cellular protein required for virus spread from cell to cell and virus-induced polykaryocytosis", Proceedings of the National Academy of Science USA, Mar. 1996, vol. 93, pp. 1836-1840.
Montgomery et al., "Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family", Cell, Nov. 1, 1996, vol. 87, pp. 427-436.
La Jolla Institute for Allergy and Immunology
Mosher Mary E.
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