Ligand for G-protein coupled receptor FPRL2

Details Ligand for G-protein coupled receptor FPRL2 Ligand for G-protein coupled receptor FPRL2

2008-03-13

2010-02-09

Li, Ruixiang (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000

Reexamination Certificate

active

07659251

ABSTRACT:
The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of FPRL2 polypeptide signalling.

REFERENCES:
patent: WO 0119860 (2001-03-01), None
patent: WO-01/75067 (2001-10-01), None
De Yang, et al.; “Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation”; Journal of Leukocyte Biology; vol. 72; No. 3; Sep. 2002; pp. 598-607.
Le Yingying et al.; “The Role of Formyl Peptide Receptors in Microbial Infection and Inflammation”; Current Medicinal Chemistry—Anti-Infective Agents; vol. 2; No. 1; Mar. 2003; pp. 83-93.
Thierry Christophe, et al.; “The Synthetic Peptide Trp-Lys-Tyr-Met-Val-Met-NH2Specifically Activates Neutrophils through FPRL1/Lipoxin A4Receptors and Is an Agonist for the Orphan Monocyte-expressed Chemoattractant Receptor FPRL2*”; The Journal of Biological Chemistry, American Society of biological Chemists,Baltimore MD; vol. 276; No. 24; Jun. 15, 2001; pp. 21585-21593.
Shigeru Taketani, et al.; “Molecular Characterization of a Newly Identified Heme-binding Protein Induced during Differentiation of urine Erythroleukemia Cells*”; The Journal of Biological Chemistry; vol. 273; No. 47; Nov. 20, 1998; pp. 31388-31394.
B. Jacob Bklackmon, et al.; “Characterization of a human and mouse tetrapyrrole-binding protein”; Archives of Biochemistry and Biophysics; vol. 407; No. 2; Nov. 15, 2002; pp. 196-201.
Isabelle Migeotte, et al.; “Identification and characterization of an endogenous chemotactic ligand specific for FPRL2”; Journal of Experimental Medicine; vol. 201; No. 1; Jan. 3, 2005; pp. 83-93.
S. Costagliola, et al.; “Genetic Immunization Against the Human Thyrotropin Receptor Causes Thyroiditis and Allows Production of Monoclonal Antibodies Recognizing the Native Receptor”; Journal of Immunology; vol. 160, No. 3; Feb. 1, 1998; pp. 1458-1465.
Asa Betten, et al.; “A proinflammatory peptide fromHelicobacter pyloriactivates monocytes to induce lymphocyte dysfunction and apoptois”; The Journal of Clinical Investigation; vol. 108; No. 8; Oct. 2001; pp. 1221-1228.
MichaelC. Braun, et al.; “Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes”; Blood; vol. 97; No. 11; Jun. 1, 2001; pp. 3531-3536.
Philip M. Murphy, et al.; “A Structural Homologue of the N-Formyl Peptide Receptor Characterization and Chromosome Mapping of a Peptide Chemoattractant Receptor Family”; The Journal of Biological Chemistry; vol. 267, No. 11; Apr. 15, 1992; pp. 7637-7643.
T. Gudermann, et al.; “Receptors and G proteins as primary components of transmembrane signal transduction”; J. Mol. Med.; 1995; vol. 73; pp. 51-63.
Francois Boulay, et al.; “The Human N-Formylpeptide receptor. Characterization of Two cDNA Isolates and Evidence for a New Subfamily of G-Protein-Coupled Receptors”; Biochemistry; 1990; vol. 29; pp. 11123-11133.
Richard D. Ye, et al.; “Isolation of a cDMA That Encodes a Novel Granulocyte N0-Formyl Peptide Receptor”; Biochemical and Biophysical Research Communications; vol. 184; No. 2; Apr. 30, 1992; pp. 582-589.
Francois Boulay, et al.; “Synthesis and Use of a Novel N-Formyl Peptide Derivative to Isolate a Human N-Formyl Peptide receptor cDNA”; Biochemical and Biophysical Research Communications; vol. 168; No. 3; May 16, 1990; pp. 1103-1109.
International Search Report.

Affiliated with

Also associated with

Rating

Ligand for G-protein coupled receptor FPRL2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ligand for G-protein coupled receptor FPRL2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligand for G-protein coupled receptor FPRL2 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4198063