Ligand determination of spin labeled compounds by receptor displ

Details Ligand determination of spin labeled compounds by receptor displ Ligand determination of spin labeled compounds by receptor displ

1974-06-24

1976-06-29

Ore, Dale R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393R, 260241, 260285, 26029376, 260295R, 260302R, 260307R, 2603096, 26032662, 23230R, 424 2, 424 9, 424330, C07D20714

Patent

active

039667642

ABSTRACT:
Compounds are provided for use in assays of organic compounds, where organic compounds of biological interest are determined at extremely low concentrations by combining in a medium, the composition to be determined, hereinafter referred to as ligand, a high molecular weight material of at least 10,000 molecular weight, which has a site spatially characteristic of the ligand, hereinafter referred to as receptor, and an analog of the ligand having a free radical functionality, hereinafter referred to as "ligand analog". The ligand analog and ligand in the medium compete for the receptor site, the amount of ligand analog bound to the receptor, being dependent on the amount of ligand present in the medium. By following the change in electron spin resonance spectrum of the ligand analog and comparing it to the change in spectrum which would be obtained in the absence of any ligand, the amount of ligand can be determined.

REFERENCES:
patent: 3818008 (1974-06-01), Eberle
patent: 3821204 (1974-06-01), Enders

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