Ligand-coupled initiator polymers and methods of use

Details Ligand-coupled initiator polymers and methods of use Ligand-coupled initiator polymers and methods of use

2003-04-10

2010-10-26

Jung, Unsu (Department: 1641)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C424S078080, C424S078170, C424S193100, C424S194100, C435S007100, C435S174000, C514S592000, C514S601000, C516S150000, C516S911000, C522S087000, C522S088000, C522S904000, C623S920000

Reexamination Certificate

active

07820158

ABSTRACT:
Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

REFERENCES:
patent: 4908404 (1990-03-01), Benedict
patent: 5332475 (1994-07-01), Mechanic
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5494940 (1996-02-01), Unger et al.
patent: 5529914 (1996-06-01), Hubbell et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5779673 (1998-07-01), Roth et al.
patent: 5834274 (1998-11-01), Hubbell et al.
patent: 5858653 (1999-01-01), Duran
patent: 5897955 (1999-04-01), Drumheller
patent: 6007833 (1999-12-01), Chudzik et al.
patent: 6060582 (2000-05-01), Hubbell et al.
patent: 6169100 (2001-01-01), Ikeda et al.
patent: 6258870 (2001-07-01), Hubbell et al.
patent: 6410044 (2002-06-01), Chudzik et al.
patent: 7427415 (2008-09-01), Scharp et al.
patent: 2002/0165337 (2002-11-01), Wallace et al.
patent: 2004/0202774 (2004-10-01), Chudzik
patent: WO 01/85180 (2001-11-01), None
Schwanstecher, M. et al. Photoaffinity labeling of the cerebral sulfonylurea receptor using a novel radioiodinated azidoglibenclamide analogue. J. Neurochem. 1994;63:698-708.
Aguilar-Bryan, L. et al. Photoaffinity labeling and partial purification of the beta cell sulfonylurea receptor using a novel, biologically active glyburide analog. J. Biol. Chem. 1990;265:8218-8224.
Kramer, W. et al. Direct photoaffinity labeling of the putative sulfonylurea receptor in rat beta-cell tumor membranes by [3H]-glibenclamide. FEBS Lett. 1988;229:355-359.
Bayley, H. & Knowles, J.R. Photoaffinity labeling. Methods Enzymol. 1977;46:69-114.
Mellott et al., “Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization,” Biomaterials 22, pp. 929-941 (2001).
Seyfert et al., “Adhesion of leucocytes to microscope slides as influenced by electrostatic interaction,” Biomaterials 16, pp. 201-207 (1995).
Uludag, H., et al.,Technology of mammalian cell encapsulation, Advanced Drug Delivery Reviews, vol. 42, pp. 29-64 (2000).
Hwang, J.S., et al,Synthesis of sulfonylurea conjugated copolymer via Peo spacer and its in vitro short-term bioactivity in insulin secretion from islets of Langerhans, Biomaterials, vol. 19, pp. 1189-1195 (1998).
Park, K.-H., et al.,Determination of the Specific Interaction between Sulfonylurea-Incorporated Polymer and Rat Islets, J. Biochem., vol. 131, pp. 359-364 (2002).
Park, K.-H., et al.,Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion, J. Biomed. Mater. Res., 55:72-78 (2001).
Park, K.-H., et al.,Incorporation of sulfonylurea into sugar-carrying polymers and their effects on insulin secretion from MIN6 cells in a solution state, J. Biomater. Sci. Polymer Edn., vol. 12, No. 8, pp. 911-920 (2001).
Gopalakrishnan, M., et al.,Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichloropheny1)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1 ,8(2H,5H)-acridinedione(A-184209)as a novel KATP ,channel inhibitor, British Journal of Pharmacology, vol. 138, pp. 393-399 (2003).
Hastedt, K. and Panten, U.,Inhibition of ATP-sensitive K+-channels by a sulfonylurea analogue with a phosphate group, Biochemical Pharmacology, vol. 65, pp. 599-602 (2003).
Cruise, G.M., et al.,In Vitro and In Vivo Performance of Porcine Islets Encapsulated in Interfacially Photopolymerized Poly(Ethylene Glyco)Diacrylate Membranes, Cell Transplantation, vol. 8, pp. 293-306 (1999).

Affiliated with

Also associated with

Rating

Ligand-coupled initiator polymers and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ligand-coupled initiator polymers and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ligand-coupled initiator polymers and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4207045