Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1995-03-24
1996-07-09
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
514622, 514653, 514654, 514818, A61L 904, A61K 31165, A61K 31135
Patent
active
055342426
ABSTRACT:
Clear and stable aerosol formulations including both lidocaine base and vasoconstricting agents have been produced. This combination of medicaments are dissolved in suitable hydrofluorocarbon propellants with additional organic solvent as required. The lidocaine base serves to improve the solubility of the vasoconstricting agent and reduce the concentration of organic solvent required. This aerosol combination is designed for nasal application to cause topical anesthesia and concomitant vasoconstriction in preparation for nasal examination or instrumentation. It is also suitable for application to other anatomical sites such as the upper airway, anus and genital tract.
REFERENCES:
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patent: 5190029 (1993-03-01), Byron et al.
patent: 5225183 (1993-07-01), Purewal et al.
Paul J. Atkins et al., "The Design and Development of Inhalation Drug Delivery Systems" pp. 155-185. (1992).
Folke Moren. "Aerosol dosage forms and formulations" Aerosols in Medicine, Principles, Diagnosis and Therapy 2nd Edition. 1993, pp. 321-350.
Michael Whitham et al. "Alternative Propellants: Proprietary Rights, Toxicological Issues and Projected Licensing Problems" Respiratory Drug Delivery IV, May 1-6, 1994.
Byron et al., "Some Aspects of Alternative Propellant Solvency" Respiratory Drug Delivery IV, May 1-6, 1994.
Dalby et al,, "CFC Propellant Substitution: P-134a as a Potential Replacement for P-12 in MDIs" Pharmaceutical Technology Mar. 1990.
CA118:87647, Fassberg et al., 1992.
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