Library of a collection of cells

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S091200, C536S023100

Reexamination Certificate

active

07838287

ABSTRACT:
The present invention relates to combinatorial gene expression libraries and methods for making these. Such libraries are useful in discovery of novel and/or enhanced metabolic pathways leading to the production of novel compounds for e.g drug discovery and/or to the production of known compounds in novel quantities or in novel compartments of the cells. The expression libraries in particular are composed of host cells capable of co-ordinated and controllable expression of large numbers of heterologous genes in the host cells.

REFERENCES:
patent: 5316922 (1994-05-01), Brown et al.
patent: 5783431 (1998-07-01), Peterson et al.
patent: 5824485 (1998-10-01), Thompson et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 5958672 (1999-09-01), Short
patent: 6001574 (1999-12-01), Short et al.
patent: 6004788 (1999-12-01), Short
patent: 6025155 (2000-02-01), Hadlaczky et al.
patent: 6030779 (2000-02-01), Short
patent: 6054267 (2000-04-01), Short
patent: 6057103 (2000-05-01), Short
patent: 6117679 (2000-09-01), Stemmer
patent: 6136567 (2000-10-01), Duchars et al.
patent: 6165793 (2000-12-01), Stemmer
patent: 6174673 (2001-01-01), Short et al.
patent: 6268140 (2001-07-01), Stuart
patent: 6294325 (2001-09-01), Wetmur
patent: 7052876 (2006-05-01), Finney et al.
patent: 7105297 (2006-09-01), Minshull et al.
patent: 2001/0041333 (2001-11-01), Short et al.
patent: 2002/0025517 (2002-02-01), Minshull et al.
patent: 2004/0110174 (2004-06-01), Goldsmith et al.
patent: 2005/0019924 (2005-01-01), Hitzeman et al.
patent: 2005/0158860 (2005-07-01), Goldsmith et al.
patent: 2005/0164162 (2005-07-01), Sorensen et al.
patent: 2006/0068472 (2006-03-01), Caldwell et al.
patent: 2006/0252156 (2006-11-01), Goldsmith et al.
patent: 0329203 (1984-01-01), None
patent: 89/10566 (1989-11-01), None
patent: WO 91/00920 (1991-01-01), None
patent: 95/08647 (1995-03-01), None
patent: 95/11986 (1995-05-01), None
patent: WO 96/34112 (1996-10-01), None
patent: 97/31118 (1997-08-01), None
patent: WO 97/35966 (1997-10-01), None
patent: WO 97/40183 (1997-10-01), None
patent: 97/44470 (1997-11-01), None
patent: WO 98/01573 (1998-01-01), None
patent: WO 98/17811 (1998-04-01), None
patent: WO 98/31837 (1998-07-01), None
patent: 98/38490 (1998-09-01), None
patent: 98/41869 (1998-09-01), None
patent: 98/54339 (1998-12-01), None
patent: 98/58085 (1998-12-01), None
patent: WO 99/10539 (1999-03-01), None
patent: 99/35260 (1999-07-01), None
patent: WO 99/45154 (1999-09-01), None
patent: WO 00/04190 (2000-01-01), None
patent: 00/08212 (2000-02-01), None
patent: WO 00/06715 (2000-02-01), None
patent: 00/17643 (2000-03-01), None
patent: WO 00/12680 (2000-03-01), None
patent: WO 00/52180 (2000-09-01), None
patent: WO 00/53744 (2000-09-01), None
patent: WO 00/58517 (2000-10-01), None
patent: WO 00/77262 (2000-12-01), None
patent: 01/32829 (2001-05-01), None
patent: WO 01/73000 (2001-10-01), None
patent: 02/059290 (2002-08-01), None
patent: 02/059296 (2002-08-01), None
patent: 02/059297 (2002-08-01), None
patent: 02/059330 (2002-08-01), None
patent: 03/062419 (2003-07-01), None
patent: 03/106639 (2003-12-01), None
patent: 2004/016791 (2004-02-01), None
Pierce et al. PNAS 89:2056-2060; 1992.
Jeffrey L. Stein et al., Nucleotide sequence and expression of a deep-sea ribulose-1,5,—bisphospate carboxylase gene cloned from a chemoautotropic bacterial endosymbiont, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 8850-8854, Nov. 1990.
T. Lotan et al., Cloning and expression inEscherichia coliof the gene encoding β-C-4-oxygenase, that coverts β carotene to the ketocarotenoid canthaxanthin inHaematococcus pluvialis, FEBS letters 364, 1995, pp. 125-128.
J. Staudinger, Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system., J Biol Chem. Mar. 5, 1993; 268(7): 4608-11. Abstract only.
Raphael Nir et al., Flow cytometry sorting of viable bacteria and yeasts according to β-galactosidase activity, Applied and environmental microbiology, Dec. 1990, p. 3861-3866, vol. 56, No. 12.
P. J. McCormack et al., Production of antibacterial compounds by phylloplane-inhabiting yeasts and yeastlike fungi, Applied and environmental microbiology, Mar. 1994, p. 927-931, vol. 60, No. 3.
Smith, et al., Construction and Use of Signal Sequence Selection Vectors inEscherichia coliandBacillus subtilis, Journal of Bacteriology, vol. 169, No. 7, pp. 3321-3328, Jul. 1987.
Gift et al., “FACS-based isolation of slowly growing cells: Double encapsulation of yeast in gel microdrops,” Nature Biotechnology, 14:884-887 (1996).
International Search Report for WO 2002/059290 mailed Dec. 23, 2002.
International Search Report for WO 2002/059296 mailed Oct. 23, 2002.
International Search Report for WO 2002/059297 mailed Jan. 15, 2003.
International Search Report for WO 2003/062419 mailed Jun. 11, 2003.
International Search Report for WO 2004/016791 mailed Dec. 5, 2003.
Leahy et al., “Transcription from plasmid expression vectors is increased up to 14-fold when plasmids are transfected as concatemers,” Nucleic Acids Research, 25(2):449-450 (1997).
Zhu et al., “Three-Color Flow Cytometry Analysis of Tricistronic Expression of eBFP, eGFP, and eYFP Using EMCV-IRES Linkages,” Cytometry, 37:51-59 (1999).
Blattner et al., “The Complete Genome Sequence ofEscherichia coliK-12,” Science, 277:1453-1462 (Sep. 5, 1997).
Diatchenko et al., “Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries,” PNAS, 93:6025-6030 (Jun. 1996).
Carninci et al., “Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes,” Genome Res., 10:1617-1630 (2000).
Wood et al., “Complementary DNA Coding Click Beetle Luciferases Can Elicit Bioluminescene of Different Colors,” Science, 244:700-702 (May 12, 1989).
Sehested et al., “Chinese Hamster Ovary Cells Resistant to the Topoisomerase II Catalytic Inhibitor ICRF-159: A Typr49Phe Mutation Confers High-Level Resistance to Bisdioxopiperazines,” Cancer Research, 58:1460-1468 (Apr. 1, 1998).
Weinshilbourn, R.M. et al., “Sulfotransferase molecular biology: cDNAs and genes,” The FASEB Journal, 11:3-14 (Jan. 1997).
Bouska. et al., “Improving the in Vivo Duration of 5-Lipoxygenase Inhibitors—Application of an in Vitro Glucuronosyltransferase Assay,” Drug Metab. Dispos., 25(9):1032-1038 (1997).
Burke et al., “Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors,” Science, 236:806-812 (May 15, 1987).
Foster, Barbara et al., “Pharmacological Rescue of Mutant p53 Conformation and Function,” Science, 286:2507-2510 (1999).
Bonaldo et al., “Normalization and Subtraction: Two Approaches to Facilitate Gene Discovery,” Genome Research, 6:791-806 (1996).
Benderitter, M. et al., “Simultaneous analysis of radio-induced membrane alteration and cell viability by flow cytometry,” Cytometry, 39(2):151-157 (2000).
Sears, D.D. et al., “An Implanted Recombination Hot Spot Stimulates Recombination and Enhances Sister Chromatid Cohesion of Heterologous YACs During Yeast Meiosis,” Genetics, 138:1055-1065 (Aug. 26, 1994).
Chen and Struhl, “Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element,” EMBO J., 4(12):3273-3280 (1985).
Chang, LMS, et al., “Deoxynucleotide-polymerizing Enzymes of Calf Thymus Gland,” J. Biol. Chem., 246:909-916 (Feb. 25, 1971).
Davis, CA et al., “Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast,” Nucleic Acids Res., 28(8):1700-1706 (Mar. 1, 2000).
Sive et al., “A simple subtractive hybridization technique emplmoying phoactivatable biotin and phenol extraction,” Nucleic Acid Res., 16:10937 (Sep. 29, 1988).
Salerno et

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Library of a collection of cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Library of a collection of cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Library of a collection of cells will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4208542

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.