Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-05-11
2008-07-15
Riley, Jezia (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025300, C536S025320, C536S026600, C530S391100, C530S402000, C435S006120
Reexamination Certificate
active
07399846
ABSTRACT:
A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods.
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Elder John Kenneth
Hamilton Alan Lewis
Housby John Nicholas
Shchepinov Mikhail Sergeevich
Southern Edwin Mellor
Lahive & Cockfield LLP
Oxford Gene Technology IP Limited
Riley Jezia
Williams Megan E.
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