LHRH preparations for intranasal administration

Details LHRH preparations for intranasal administration LHRH preparations for intranasal administration

1990-09-20

1992-05-26

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514800, 530320, A61K 3702

Patent

active

051168170

ABSTRACT:
The present invention relates to a novel nasal composition comprising a nona- or decapeptide having LHRH agonist or antagonist activity and a surfactant which is a bile acid or a pharmaceutically acceptable salt thereof in a buffered aqueous solution.

REFERENCES:
patent: 4118483 (1978-10-01), Konig et al.
patent: 4156719 (1979-05-01), Sezaki et al.
patent: 4261887 (1981-04-01), Amoss et al.
patent: 4476116 (1984-10-01), Anik
Hirai et al., International Journal of Pharmaceutics, 9, 165-172 (1981).
Pontiroli et al., British Medical Journal, 284, 303-306 (1982).
Beattie et al., Journal of Medicinal Chemistry, 18, No. 12, 1247-1250 (1975).
Okada et al., Journal of Pharmaceutical Science, vol. 71, No. 12, 1367-1371 (1982).
The Merck Index, 9th Ed., Merck & Co., Inc., Rahway, N.J. 1976, p. 583, entry No. 4330.

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