LHRH antagonists having modified aminoacyl residues at positions

Details LHRH antagonists having modified aminoacyl residues at positions LHRH antagonists having modified aminoacyl residues at positions

1994-07-28

1996-02-13

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

530328, A61K 3824, C07K 723

Patent

active

054912172

ABSTRACT:
A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or .OMEGA.-(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.

REFERENCES:
patent: 4317815 (1982-03-01), Coy et al.
patent: 4481190 (1984-11-01), Nestor et al.
patent: 4530920 (1985-07-01), Nestor et al.
patent: 4667014 (1987-05-01), Nestor et al.
patent: 4866160 (1989-09-01), Coy et al.
patent: 5073624 (1991-12-01), Coy et al.
Abstract No. 869 from the 74th Annual Meeting Program and Abstracts of the Endocrine Society Meeting, San Antonio, TX, Jun. 24-27, 1992, C. A. Pampen, et al., "Characterization of a New Selective GnRH Antagonist with Potent Antiovulatory Activity and Extremely Low Anaphylactoid Activity".
Jean Rivier, et al., J. Med. Chem., 3 5: 4270-4278 (1992, "Gonadotropin-Releasing Hormone Antagonists with N.omega.-Triazolylornithine, -lysine, or -p-aminophenylalanine Residues at Positions 5 and 6."
P. Theobald, et al., J. Am. Chem. Soc. 112: 9624-9626 (1990).
P. Theobald, et al., J. Am. Chem. Soc. 34: 2395-2402 (1991).

Affiliated with

Also associated with

Rating

LHRH antagonists having modified aminoacyl residues at positions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with LHRH antagonists having modified aminoacyl residues at positions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and LHRH antagonists having modified aminoacyl residues at positions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-241435