LHRH antagonists having lactam groups at the N-terminus

Details LHRH antagonists having lactam groups at the N-terminus LHRH antagonists having lactam groups at the N-terminus

1994-12-08

1996-05-14

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530313, 930130, A61K 3809, C07K 723

Patent

active

055167594

ABSTRACT:
Peptides possessing LHRH antagonistic activity, and useful for the controlling the release of LHRH in mammals are decapeptide analogues of LHRH having a lactam group at the N-terminus of the formula ##STR1## where n is 1, 2, or 3 and R.sup.1 is selected from the group consisting of hydrogen, benzyl, 4-chlorobenzyl, 2-methylnaphth-1-yl, 1-methylnaphth-2-yl, and quinolin-3-ylmethyl.

REFERENCES:
patent: 4307083 (1981-12-01), Rivier et al.
patent: 4481190 (1984-11-01), Nestor et al.
patent: 4851385 (1989-07-01), Roeske
Peptides: Synthesis, Structure, Function, Proceedings American Peptide 7th Symp., published 1981, Freidinger, "Computer Graphics and Chemical . . . ", pp. 673-683.

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