LHRH antagonists having improved solubility properties

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S328000

Reexamination Certificate

active

07148195

ABSTRACT:
The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be used for the treatment of hormone-dependent tumors and hormone-influenced non-malignant disorders.

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Haviv et al., “The Effect of NmeTyr5Substitution in Luteinizing Hormone-Releasing Hormone Antagonists”,J. Med. Chem. 36(7), 928-933, 1993.

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