Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Lutenizing hormone releasing factor ; related peptides
Patent
1988-05-23
1993-03-30
Cashion, Jr., Merrell C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Lutenizing hormone releasing factor ; related peptides
530328, 930110, 930120, 930DIG803, 930DIG801, 930DIG800, C07K 720
Patent
active
051985330
ABSTRACT:
The present invention deals with LHRH antagonists which possess improved water solubility and while having the high antagonist potency of the basic peptides, are free of the edematogenic effects. These compounds are highly potent in inhibiting the release of gonadotropins from the pituitary gland in mammals, including humans.
The compounds of this invention are represented by the formula
REFERENCES:
patent: 3250759 (1966-05-01), Bodanszky et al.
patent: 4800191 (1989-01-01), Schally et al.
Ljunggvist et al, Biochem. & Biophys. Res. Com. pp. 849-856, vol. 148, No. 2, 1987.
Dutta et al, J. Med. Chem., vol. 21, pp. 1018-1024, 1978.
Bajasz et al, PNAS, vol. 85, pp. 1637-1641, 1988.
M. Karten and J. E. Rivier, Endocrine Reviews, 7, 44-66 (1986).
D. H. Coy, et al. Peptides: Structure and Biological Function, 775-779, (1979).
J. L. Pineda, et al., Journal of Clin. Endocrinology and Metabolism 421-422 (1980).
Coy, et al., vol. 110, No. 4, Endocrinology 1445-1447 (1982).
Schmidt, et al., Contraception vol. 29, No. 3, (Mar. 1984).
Morgan, et al., Int. Archs Allergy appl. Immun. 80: 70-75 (1986).
Vickery, et al, LHRH and Its Analogs, MTP Press, Ltd., 11-22 (1984).
Activities of Sntagonists of the Luteinizing Hormone Releasing Hormone with Emphasis on Positions 1, 5 and 6, etc. Folkers, et al., Biomed Research Chemical Abstracts, vol. 82, (1975), 73465h, p. 488.
Chemical Abstracts, vol. 110 (1989), 110:186130k, p. 94.
Bajusz Sandor
Schally Andrew V.
Behr Omri M.
Cashion Jr. Merrell C.
McDonald Matthew J.
The Administrators of the Tulane Educational Fund
Wessendof T. D.
LandOfFree
LHRH antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with LHRH antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and LHRH antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1281950