LHRH antagonist analogs having low histamine-release activity

Details LHRH antagonist analogs having low histamine-release activity LHRH antagonist analogs having low histamine-release activity

1987-07-15

1989-07-25

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514800, 530313, A61K 3743, C07K 720

Patent

active

048513857

ABSTRACT:
Antagonist analogs of luteinizing hormone-releasing hormone (LHRH) having N-alkylated basic amino acid residues at the 8 position, 8 and 6 positions, 8 and 5 positions, and 8, 6 and 5 positions, having high antiovulatory activity and low histamine release activity, and their use in regulating the release of gonadatropic hormones from the pituitary gland of mannals.

REFERENCES:
patent: 4317815 (1982-03-01), Coy et al.
patent: 4431635 (1984-02-01), Coy et al.
patent: 4481190 (1984-11-01), Nestor et al.
patent: 4504414 (1985-03-01), Folkers et al.
patent: 4652550 (1987-03-01), Rivier et al.
patent: 4689396 (1987-08-01), Roeske et al.
patent: 4740500 (1988-04-01), Vale, Jr. et al.

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