LHRH analogues with cytotoxic moieties at the sixth position

Details LHRH analogues with cytotoxic moieties at the sixth position LHRH analogues with cytotoxic moieties at the sixth position

1991-06-03

1993-11-02

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

530328, 530816, 530810, 424 859, 424 8591, 930110, C07K 720, C07K 706

Patent

active

052584925

ABSTRACT:
The present invention deals with LHRH analogues which contain cytotoxic moieties and have influence on the release of gonadotropins from the pituitary gland of mammals, including humans. The compounds of this invention are represented by the formula:

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patent: 4761398 (1988-08-01), Edens et al.
Jennes et al, Peptides, vol. 7, pp. 459-463, (1986).
Folkers et al, Chem. Abs., vol. 97 (13), 104360m, (1982).
Bajusz et al, Chem. Abs., vol. 112 (1), 790 p, (1989).
Hocart et al, Chem. Abs., vol. 101 (3), 17549n, (1983).
Rosenberg et al, Nature, vol. 222, Apr. 26 1969, pp. 385-386.
Maier, Naturwissenschaften, vol. 74 (1987), pp. 374-382.

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