LHRH analogues with cytotoxic moieties at the sixth position

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Lutenizing hormone releasing factor ; related peptides

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Details

530328, 530816, 530810, 424 859, 424 8591, 930110, C07K 720, C07K 706

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active

052584925

ABSTRACT:
The present invention deals with LHRH analogues which contain cytotoxic moieties and have influence on the release of gonadotropins from the pituitary gland of mammals, including humans. The compounds of this invention are represented by the formula:

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Rosenberg et al, Nature, vol. 222, Apr. 26 1969, pp. 385-386.
Maier, Naturwissenschaften, vol. 74 (1987), pp. 374-382.

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