LHRH analogs

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Lutenizing hormone releasing factor ; related peptides

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Details

530328, C07K 720, A61K 3724

Patent

active

051109042

ABSTRACT:
The present invention relates to novel "pseudo" nonapeptide and decapeptide derivatives of LHRH. More particularly the present invention relates to derivatives of LHRH wherein the nitrogen atom of at least one of the amide bonds has been alkylated.

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patent: 5003011 (1991-03-01), Coy et al.
Thiasrivongs et al., J. of Hypertension, 7, (suppl. 2): 521-523, 1989.
Stewart et al., Solid Phase Peptide Synthesis, Pierce Chem. Co., 1984.
Coy et al., J. Med. Chem. 19 423 (1976).

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