Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1983-09-16
1986-08-19
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4351722, 435240, 935 96, 935 99, 935102, 935103, 935106, 935110, 436513, 436528, 436540, 436548, 424 11, 424 85, G01N 33544, G01N 33541, C12N 1500, C12N 500
Patent
active
046070095
ABSTRACT:
An assay for determining the Lewis blood group of a patient consists of testing a body sample for the presence of Lewis.sup.a and Lewis.sup.b antigens. Monoclonal antibodies specific for either of these antigens are employed which do not cross-react with other related antigens, such as the H blood antigen. Body samples which may be tested include: saliva, serum, urine, and paraffin-embedded tissue samples. Hybridoma cell lines and the antibody compositions they produce specific for these antigens are provided for use in the assay.
REFERENCES:
Herlyn et al., "Colorectal Carcinoma--Specific Antigen: Detection by Means of Monoclonal Antibody," Proc. Natl. Acad. Sci., USA, vol. 76, pp. 1438-1442 (Mar. 1979).
Young et al., "Characterization of Monoclonal Ab Specific for the Lewis a Human Blood Group Determinant," J. of Biol. Chem., vol. 258, pp. 4890-4894 (Apr. 1983).
Rohr et al., "Production of Mouse Monoclonal Antibiodies to Blood Group Active Oligosaccharide", Fed. Proc., 42(3): 1983 (Apr.), p. 432, Abt: 815.
Race & Sanger, Blood Groups in Man, pp. 323-349 (6th Ed., 1975).
Koprowski et al, The Lancet, Jun. 12, 1982, pp. 1332-1333.
Brockhaus et al, J. Biol. Chem., 256, pp. 13223-13225.
Blaszczyk et al, Second Annual Congress for Hybridoma Research, Abstract.
Journal of Immunological Methods, 62 (1983), pp. 73-78.
Magnani, Second Annual Congress for Hybridoma Research, Abstract.
Herlyn Meenhard
Koprowski Hilary
Steplewski Zenon
Shapiro Lionel M.
The Wistar Institute
Weimar Elizabeth C.
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