Levorotatory N-substituted acylmorphinans useful as analgesic ag

Details Levorotatory N-substituted acylmorphinans useful as analgesic ag Levorotatory N-substituted acylmorphinans useful as analgesic ag

1981-11-09

1983-02-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 74, A61K 31485, C07D22128

Patent

active

043741398

ABSTRACT:
Levorotatory N-substituted acylmorphinans of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkenyl, cycloalkyl-lower alkyl, cyano-lower alkyl, aryl-lower alkyl, or 5- or 6-membered heterocyclic-lower alkyl, and one of R.sub.2 or R.sub.3 is hydrogen and the other of R.sub.2 or R.sub.3 is alkanoyl of 2 to 7 carbon atoms, aroyl, trifluoromethylcarbonyl or ##STR2## wherein R is hydrogen or lower alkyl and n is an integer of 0 to 6, and salts thereof with pharmaceutically acceptable acid addition salts, are described. The compounds of formula I are useful as analgesic agents.

REFERENCES:
patent: 3723437 (1973-03-01), Wiesner
patent: 3914233 (1975-10-01), Mohacsi et al.
Belanger, et al., J. Org. Chem., vol. 43, No. 5, pp. 906-909 (1978).

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