Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1998-02-18
2000-07-18
Guzo, David
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
4353201, 4353723, 536 245, C12N 900, C12N 1563, C07H 2104
Patent
active
060906022
ABSTRACT:
An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved by delivering the antiretroviral to the infected system, wherein the reverse transcription process is inhibited via steric hindrance, halting the viral RNA replication. Delivery may be accomplished by conventional methods, such as via oral dosing or injection. Additional delivery methods are also contemplated, including packaging in liposomes and protein targeting. The composition and method are also useful for inhibiting the proliferation of cancer cells by halting the transcription process.
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Rafool Gordon J.
Thompson Daryl L.
Tillman Timothy N.
Guzo David
Promelas Research Corporation
Shibuya Mark L.
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