Leukotriene receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Details

C530S324000, C530S325000, C530S326000, C530S327000, C435S007210, C436S501000

Reexamination Certificate

active

06939953

ABSTRACT:
The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.

REFERENCES:
patent: WO 99/42484 (1999-08-01), None
Devchand, P. R., et al., The PPARα-leukotriene B4pathway to inflammation control.Nature384. 39-43 (1996).
Devchand, P. R., et al., Chemical Probes That Differentially Modulate Peroxisome Proliferator-activated Receptor α and BLTR, Nuclear and Cell Surface Receptors for Leukotriene B4J. Biol. Chem.274(33), 23341-23348 (1999).
Lynch, K. R., et al., Characterization of the human cysteinyl leukotriene CysLT1receptor.Nature399. 789-793 (1999).
Martin, V., et al., Leukotriene Binding, Signaling, and Analysis of HIV Coreceptor Function in Mouse and Human Leukotriene B4Receptor-transfected Cells.J. Biol. Chem.274(13), 8597-8603 (1999).
Samuelsson, B., et al., Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological EffectsScience237, 1171-1176 (1987).
Sarau, H. M., et al., Identification, Molecular Cloning, Expression, and Characterization of a Cysteinyl Leukotriene Receptor,Mol Pharmacol. 56, 657-663 (1999).
Yokomizo, T., et al., A G-protein-coupled receptor for leukotriene B4that mediates chemotaxis,Nature387(5), 620-624 (1997).
Akbar, et al., Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells,J. Biol. Chem.271(31):18363-18367 (1996).

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