Leukotriene by amides and hydrazides

Details Leukotriene by amides and hydrazides Leukotriene by amides and hydrazides

1988-08-01

1990-09-04

Phillips, Delbert R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2604045, 260404, 548548, C07D207404, C11C 300

Patent

active

049546384

ABSTRACT:
Leukotrienes may be conjugated with various proteins such as Bovine Serum Albumin (BSA) and Hemocyanin from Giant Keyhole Limpets (KLH) using 1,5-difluoro-2,4-dinitrobenzene or 6-N-maleimidohexanoic acid chloride as coupling agents.
These conjugates are useful as reagents in a newly developed immunoassay for leukotrienes, as well as having potential utility as chemical immunotherapeutic agents in the treatment of various allergic and chronic inflammatory diseases of the skin, lung, and airways, including asthma, allergic rhinitis, rheumatoid arthritis, and skin diseases such as psoriasis and eczema.

REFERENCES:
patent: 4767745 (1988-08-01), Young et al.
Prostaglandins, vol. 26, No. 4, (1983), pp. 605-613, Young et al.
Prostaglandins Leukotrienes and Medicine 13: 21-25, (1984).

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