Leukotriene B4 as an antiviral and anti-neoplastic agent

Details Leukotriene B4 as an antiviral and anti-neoplastic agent Leukotriene B4 as an antiviral and anti-neoplastic agent

1997-02-11

1998-08-04

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

560128, A61K 3120, C07C 69587

Patent

active

057894418

ABSTRACT:
The present invention relates to the use of the antiviral activity of leukotriene B.sub.4 (LTB.sub.4), variants and derivatives thereof as a therapeutic agent in viral infections caused by human and animal viruses. The present invention also relates to the use of LTB.sub.4 as an anti-neoplastic agent in the prophylaxis and treatment of cancers induced by tumor viruses and in other neoplasic diseases. The human and animal viruses are DNA viruses, such as parvoviridae, papovaviridae, adenoviridae, herpesviridae, poxviridae and hepadnaviridae; RNA viruses, such as picornaviridae, togaviridae, orthomyxoviridae, paramyxoviridae, coronaviridae, reoviridae, oncornaviridae and filoviridae in general, and Retroviridae such as HIV-1 and HIV-2.

REFERENCES:
Shankland et al. "Activity of topically applied leukotriene . . . " CA 119:21047, 1993.
Becker et al. "Exposure to nitric acid . . . " CA 124:253021, 1996.
Demitsu et al. "Phagocytosis and bacterial action of mouse . . . " CA 112:53565, 1990.
Schroeder et al. "Avarol restore the altered prostaglandin . . . " CA 116:33988, 1992.
Chung et al. "Effect of eicosanoids on induction of . . . " CA 116:52215, 1992.
Hennet et al. "A kinetic study of immune mediators . . . " CA 117:249793, 1992.
Roizman et al. "The human herpesviruses" Raven Press, pp. 1-9, 1993.
Neipel et al. "Minireview: Cell homologous genes in kaposi Sarcoma . . . " J. Virol. v.71, pp. 4187-4193, 1997.
Bevilacqua et al., PNAS USA 84:9238-9442, 1987.
Boyum A., Scand. J. Immunol., 1976, 5(5):9.
Bray, R.A. et al., J. Immunol, 1986, 136:1783.
Cecil's Text Book of Medicine chapter 164, 19th Edition, 1992.
Cotran et al., J. Exp. Med. 164:661-666, 1986.
Devchand P.R., et al., Nature 384:39, 1996.
Gagnon L., et al., Cell Immunol., 1987, 110:243.
Marleau, et al., Br. J. Pharmacol, 112:654, 1994.
Marleau, et al., J. Immunol. 150:206,1993.
Matthews and Boehms, Rev. Inf. Dis., 1988, 10, suppl. 3:490.
Mehl J.K., et al., Antimicrob. Agents Ch. 18:269, 1980.
Miller G., Virology, B.N. Fields & D.M. Knipe ed., Raven Press, 1990, pp. 1921-1958.
Reedman B.M. and Klein G., Int. J. Cancer, 11:499, 1973.
Remington's Pharmaceutical Sciences, 16th ed. Osol. A., ed., Mack, Easton PA, 1980.
Rola-Pleszycznski M. et al., Biochem. Biophys. Res. Comm., 1982, 108:1531.
Rola-Pleszczynski M. et al., Biochem. Biophys. Res. Comm., 1983, 113:531.
Rola-Pleszczynski M. et al., Prostaglandins Leukotrienes Med., 1984, 13:113.
Steinhart W.L., et al., Virology 70:241, 1976.

Affiliated with

Also associated with

Rating

Leukotriene B4 as an antiviral and anti-neoplastic agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Leukotriene B4 as an antiviral and anti-neoplastic agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukotriene B4 as an antiviral and anti-neoplastic agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1177668